917656
3-(Piperidin-4-yl)benzoic acid hydrochloride
≥95%
Synonym(s):
Semi-flexible linker for PROTAC® development
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About This Item
Empirical Formula (Hill Notation):
C12H16ClNO2
CAS Number:
Molecular Weight:
241.71
MDL number:
UNSPSC Code:
12352116
Quality Level
Assay
≥95%
form
powder
reaction suitability
reagent type: linker
functional group
carboxylic acid
storage temp.
2-8°C
SMILES string
O=C(C1=CC(C2CCNCC2)=CC=C1)O.Cl
Application
3-(Piperidin-4-yl)benzoic acid hydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.
Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
related product
Product No.
Description
Pricing
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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