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Merck
CN

91719

Trifluoroacetic anhydride

derivatization grade (GC derivatization), LiChropur™, ≥99.0% (GC)

Synonym(s):

TFAA

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About This Item

Linear Formula:
(CF3CO)2O
CAS Number:
407-25-0
Molecular Weight:
210.03
UNSPSC Code:
12352200
NACRES:
NA.22
PubChem Substance ID:
329770069
EC Number:
206-982-9
Beilstein/REAXYS Number:
746197
MDL number:
MFCD00000416
Assay:
≥99.0% (GC)
Grade:
derivatization grade (GC derivatization)
Technique(s):
gas chromatography (GC): suitable (ECD)
Bp:
39.5-40 °C (lit.)
Vapor pressure:
6.28 psi ( 20 °C)

Key Documents

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InChI key

QAEDZJGFFMLHHQ-UHFFFAOYSA-N

InChI

1S/C4F6O3/c5-3(6,7)1(11)13-2(12)4(8,9)10

SMILES string

FC(F)(F)C(=O)OC(=O)C(F)(F)F

grade

derivatization grade (GC derivatization)

vapor pressure

6.28 psi ( 20 °C)

assay

≥99.0% (GC)

form

liquid

quality

LiChropur™

reaction suitability

reagent type: derivatization reagent
reaction type: Acylations, reagent type: derivatization reagent
reaction type: Esterifications

technique(s)

gas chromatography (GC): suitable (ECD)

refractive index

n20/D 1.3 (lit.)

bp

39.5-40 °C (lit.)

mp

−65 °C (lit.)

density

1.511 g/mL at 20 °C (lit.)

storage temp.

2-8°C

Quality Level

100

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Application

Learn more in the Product Information
Suitable for derivatization of amines, aryl amines, phenolic amines, primany amines, tertiary aromatic amines, amino acids, aminoalkylphosphoric acids, 2-aminoethylphosphoric acid, 1-hydroxy-2-aminoethylphosponic acid, amphetamine, beta blocker drugs, creatinine, desipramine, dopamine, glutathione, glycol (MOPEG), guanidine drugs, histidine, n-hydroxy-2-fluorenylacetamide, n-hydroxylamines, hydroxy acids, p-hydroxyamphetamine, 4-hydroxycoumarins, p-hydroxynorephedrine, hydroxysteroids, 5-hydroxytryptamine, indoles, Iodoamino acids, carbaryl and hydroxylated metabolites, metanephrine, methylphenidate, norepinephrine, normetanephrine, peptide amide, phenformin, phenols, phentermine, phenylthiohydantoin amino acid, propranolol, sulfonamides, sulfonylureas, thiamine, vanillymandelic acid, trisubstituted ureas and urea.

Other Notes

For the protection of prim. and sec. amines; derivatives are more volatile
Reagent for cabethoxy, butyl ester, n-methyl, methyl ester, di(trifluoroacetyl), hexafluoroisopropyl ester, acetyl or trifluoroacetyl phenylthihydantoins, trifluoroacetyl (2-hydroxy-2-methyl)ethyl, n-trifluoroacetyl, trifluoroacetyl (TFA), trifluoroacetamide, 4-trifluoromethyl-2, 6-diamino-1,3,5-triazineacetyl and trifluoroacetyl vanillin.

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A

supp_hazards

EUH014

Storage Class

8B - Non-combustible corrosive hazardous materials

wgk

WGK 2

ppe

Faceshields, Gloves, Goggles

Regulatory Information

危险化学品
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Certificates of Analysis (COA)

Lot/Batch Number
BCCL7306
BCCL6394
BCCK3514
BCCH1823
BCCH6603

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Phosphonoglycan. A major polysaccharide constituent of the amoeba plasma membrane contains 2-aminoethylphosphonic acid and 1-hydroxy-2-aminoethylphosphonic acid.
E D Korn et al.
The Journal of biological chemistry, 248(6), 2257-2259 (1973-03-25)
Determination of phenformin in biological fluids using chemical ionization mass spectrometry.
S B Matin et al.
Biomedical mass spectrometry, 1(5), 320-322 (1974-10-01)
Mass fragmentography of creatinine proposed as a reference method.
I Björkhem et al.
Clinical chemistry, 23(11), 2114-2121 (1977-11-01)
Quantitative determination of guanethidine and other guanido-containing drugs in biological fluids by gas chromatography with flame ionization detection and multiple ion detection.
J H Hengstmann et al.
Analytical chemistry, 46(1), 34-39 (1974-01-01)
T.W. Greene et al.
Protective Groups in Organic Synthesis null
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