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91719

Supelco

Trifluoroacetic anhydride

for GC derivatization, LiChropur™, ≥99.0% (GC)

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Synonym(s):
TFAA
Linear Formula:
(CF3CO)2O
CAS Number:
407-25-0
Molecular Weight:
210.03
Beilstein:
746197
EC Number:
206-982-9
MDL number:
MFCD00000416
UNSPSC Code:
12000000
PubChem Substance ID:
329770069
NACRES:
NA.22

grade

for GC derivatization

Quality Level

100

vapor pressure

6.28 psi ( 20 °C)

Assay

≥99.0% (GC)

form

liquid

quality

LiChropur™

reaction suitability

reagent type: derivatization reagent
reaction type: Acylations
reagent type: derivatization reagent
reaction type: Esterifications

technique(s)

gas chromatography (GC): suitable (ECD)

refractive index

n20/D 1.3 (lit.)

bp

39.5-40 °C (lit.)

mp

−65 °C (lit.)

density

1.511 g/mL at 20 °C (lit.)

storage temp.

2-8°C

SMILES string

FC(F)(F)C(=O)OC(=O)C(F)(F)F

InChI

1S/C4F6O3/c5-3(6,7)1(11)13-2(12)4(8,9)10

InChI key

QAEDZJGFFMLHHQ-UHFFFAOYSA-N

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Application

Learn more in the Product Information
Suitable for derivatization of amines, aryl amines, phenolic amines, primany amines, tertiary aromatic amines, amino acids, aminoalkylphosphoric acids, 2-aminoethylphosphoric acid, 1-hydroxy-2-aminoethylphosponic acid, amphetamine, beta blocker drugs, creatinine, desipramine, dopamine, glutathione, glycol (MOPEG), guanidine drugs, histidine, n-hydroxy-2-fluorenylacetamide, n-hydroxylamines, hydroxy acids, p-hydroxyamphetamine, 4-hydroxycoumarins, p-hydroxynorephedrine, hydroxysteroids, 5-hydroxytryptamine, indoles, Iodoamino acids, carbaryl and hydroxylated metabolites, metanephrine, methylphenidate, norepinephrine, normetanephrine, peptide amide, phenformin, phenols, phentermine, phenylthiohydantoin amino acid, propranolol, sulfonamides, sulfonylureas, thiamine, vanillymandelic acid, trisubstituted ureas and urea.

Other Notes

For the protection of prim. and sec. amines; derivatives are more volatile
Reagent for cabethoxy, butyl ester, n-methyl, methyl ester, di(trifluoroacetyl), hexafluoroisopropyl ester, acetyl or trifluoroacetyl phenylthihydantoins, trifluoroacetyl (2-hydroxy-2-methyl)ethyl, n-trifluoroacetyl, trifluoroacetyl (TFA), trifluoroacetamide, 4-trifluoromethyl-2, 6-diamino-1,3,5-triazineacetyl and trifluoroacetyl vanillin.

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H314,H332,H412

Hazard Classifications

Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A

Supplementary Hazards

EUH014

WGK

WGK 2

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

危险化学品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Quantitative determination of guanethidine and other guanido-containing drugs in biological fluids by gas chromatography with flame ionization detection and multiple ion detection.
J H Hengstmann et al.
Analytical chemistry, 46(1), 34-39 (1974-01-01)
Determination of phenformin in biological fluids using chemical ionization mass spectrometry.
S B Matin et al.
Biomedical mass spectrometry, 1(5), 320-322 (1974-10-01)
Mass fragmentography of creatinine proposed as a reference method.
I Björkhem et al.
Clinical chemistry, 23(11), 2114-2121 (1977-11-01)
Phosphonoglycan. A major polysaccharide constituent of the amoeba plasma membrane contains 2-aminoethylphosphonic acid and 1-hydroxy-2-aminoethylphosphonic acid.
E D Korn et al.
The Journal of biological chemistry, 248(6), 2257-2259 (1973-03-25)
T.W. Greene et al.
Protective Groups in Organic Synthesis null
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