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91683

Supelco

2,2,2-Trifluoroethanol

analytical standard, for NMR spectroscopy

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Synonym(s):
Trifluoroethyl alcohol
Linear Formula:
CF3CH2OH
CAS Number:
75-89-8
Molecular Weight:
100.04
Beilstein:
1733203
EC Number:
200-913-6
MDL number:
MFCD00004672
UNSPSC Code:
12142201
PubChem Substance ID:
329770066
NACRES:
NA.24

grade

analytical standard
for NMR spectroscopy

Quality Level

100

vapor density

3.5 (vs air)

vapor pressure

70 mmHg ( 25 °C)

Assay

≥99.5% (GC)

autoignition temp.

~896 °F

expl. lim.

42 %

refractive index

n20/D 1.3 (lit.)

bp

77-80 °C (lit.)

mp

−44 °C (lit.)

density

1.373 g/mL at 25 °C (lit.)

application(s)

environmental

format

neat

SMILES string

OCC(F)(F)F

InChI

1S/C2H3F3O/c3-2(4,5)1-6/h6H,1H2

InChI key

RHQDFWAXVIIEBN-UHFFFAOYSA-N

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Application

2,2,2-Trifluoroethanol may be used as a co-solvent for the purification of certain alcohol sensitive compounds like boronic acid pinacol esters using supercritical fluid chromatography technique(SFC).

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Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Dam. 1 - Flam. Liq. 3 - Repr. 1B - STOT RE 2 Inhalation

Target Organs

Blood

WGK

WGK 1

Flash Point(F)

closed cup

Flash Point(C)

closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

危险化学品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Applications of 2, 2, 2 trifluoroethanol as a versatile co-solvent in supercritical fluid chromatography for purification of unstable boronate esters, enhancing throughput, reducing epimerization, and for additive free purifications
Asokan K, et al.
Journal of Chromatography A, 1531, 122-130 (2018)
John P Hodkinson et al.
Rapid communications in mass spectrometry : RCM, 26(16), 1783-1792 (2012-07-11)
Amyloid formation is implicated in a number of human diseases. β(2)-Microglobulin (β(2)m) is the precursor protein in dialysis-related amyloidosis and it has been shown that partial, or more complete, unfolding is key to amyloid fibril formation in this pathology. Here
Multiple aspects of the toxicity of fluroxene and its metabolite 2,2,2-trifluoroethanol.
L S Kaminsky et al.
Critical reviews in toxicology, 19(2), 87-112 (1988-01-01)
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Tetherin/Bst-2 is a cell surface protein that can act as a restriction factor against a number of enveloped viruses, including HIV-1. It acts by tethering new virus particles to the host cell membrane, promoting their internalization and degradation. Tetherin is
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In tissue engineering research, there has recently been considerable interest in using electrospun biomimetic nanofibers of hybrids, in particular, from natural and synthetic polymers for engineering different tissues. However, phase separation between a pair of much dissimilar polymers might give
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