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Glycyrrhizic acid ammonium salt

analytical standard, suitable for HPLC

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Empirical Formula (Hill Notation):
C42H62O16 · NH3
CAS Number:
53956-04-0
Molecular Weight:
839.96
EC Number:
258-887-7
MDL number:
MFCD00167400
UNSPSC Code:
85151701
PubChem Substance ID:
329770037
NACRES:
NA.24

grade

analytical standard

Quality Level

100

Assay

≥90.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care

format

neat

SMILES string

N.CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]3(C)[C@@H]2C(=O)C=C4[C@@H]5C[C@](C)(CC[C@]5(C)CC[C@@]34C)C(O)=O)O[C@H]6O[C@@H]([C@@H](O)[C@H](O)[C@H]6O[C@@H]7O[C@@H]([C@@H](O)[C@H](O)[C@H]7O)C(O)=O)C(O)=O

InChI

1S/C42H62O16.H3N/c1-37(2)21-8-11-42(7)31(20(43)16-18-19-17-39(4,36(53)54)13-12-38(19,3)14-15-41(18,42)6)40(21,5)10-9-22(37)55-35-30(26(47)25(46)29(57-35)33(51)52)58-34-27(48)23(44)24(45)28(56-34)32(49)50;/h16,19,21-31,34-35,44-48H,8-15,17H2,1-7H3,(H,49,50)(H,51,52)(H,53,54);1H3/t19-,21-,22-,23-,24-,25-,26-,27+,28-,29-,30+,31+,34-,35-,38+,39-,40-,41+,42+;/m0./s1

InChI key

ILRKKHJEINIICQ-OOFFSTKBSA-N

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Application

Glycyrrhizic acid ammonium salt may be used as a primary chemical reference standard for the quantitative determination of glycyrrhizic acid in Glycyrrhiza uralensis fisch. ex DC. plant root using high performance liquid chromatography(HPLC).
Glycyrrhizic acid ammonium salt may be used as an analytical standard for the determination of glycyrrhizic acid in biological fluids using micellar electrokinetic chromatographic technique.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

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Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319

Hazard Classifications

Eye Irrit. 2

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Determination of glycyrrhizic acid and 18-β-glycyrrhetinic acid in biological fluids by micellar electrokinetic chromatography
Wang P, et al.
Journal of Chromatography A, 811(1-2), 219-224 (1998)
The determination of glycyrrhizic acid in Glycyrrhiza uralensis Fisch. ex DC.(Zhi Gan Cao) root and the dried aqueous extract by LC?DAD
Hennell.R.J, et al.
Journal of Pharmaceutical and Biomedical Analysis, 47, 494-500 (2008)
Yu Okuma et al.
Neuropharmacology, 85, 18-26 (2014-05-27)
Glycyrrhizin (GL) is a major constituent of licorice root and has been suggested to inhibit the release of high mobility group box-1 (HMGB1), a protein considered representative of damage-associated molecular patterns. We found that GL bound HMGB1 but not RAGE
Chiung-Hung Chang et al.
PloS one, 9(8), e105362-e105362 (2014-08-19)
Salmonella, a common zoonotic pathogen, causes gastroenteritis in both humans and animals. Traditional Chinese Medicine (TCM) has been used to improve gastrointestinal dysfunction and to modify the immune response to inflammation for centuries. This study used six herbal plants and
Pil-Sung Yang et al.
Respiratory research, 15, 148-148 (2014-11-26)
High mobility group box-1 (HMGB1), a proinflammatory cytokine, plays a pivotal role in tissue remodeling and angiogenesis, both of which are crucial for the pathogenesis of pulmonary arterial hypertension. In this study, we explored the relationship between HMGB1 and pulmonary
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