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91214

Supelco

Isofraxidin

analytical standard

Synonym(s):

6,8-Dimethoxyumbelliferone, 7-Hydroxy-6,8-dimethoxychromen-2-one, 7-Hydroxy-6,8-dimethoxycoumarin

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About This Item

Empirical Formula (Hill Notation):
C11H10O5
CAS Number:
486-21-5
Molecular Weight:
222.19
Beilstein:
202652
MDL number:
MFCD00221757
UNSPSC Code:
85151701
PubChem Substance ID:
329770006
NACRES:
NA.24

grade

analytical standard

Quality Level

100

Assay

≥98.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

impurities

≤5.0% water

application(s)

food and beverages

format

neat

storage temp.

2-8°C

SMILES string

COc1cc2C=CC(=O)Oc2c(OC)c1O

InChI

1S/C11H10O5/c1-14-7-5-6-3-4-8(12)16-10(6)11(15-2)9(7)13/h3-5,13H,1-2H3

InChI key

HOEVRHHMDJKUMZ-UHFFFAOYSA-N

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General description

Isofraxidin is a major active constituent, isolated from Sarcandra glabra plant with a variety of biological properties such as antifatigue, antistress, anticancer, immunoaccomondating and cholagogic effects.

Application

Isofraxidin may be used as an analytical reference standard for the separartion and quantification of the analyte in Sarcandra glabra plant and Acanthopanax senticosus Harms using different chromatography techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCH4736
BCCF6368
BCCD2763
BCCB6662
BCCB8654

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Separation and purification of isofraxidin from Sarcandra glabra by microwave-assisted extraction coupled with high-speed counter-current chromatography
Xiao X, et al.
Separation and Purification Technology, 68(2), 250-254 (2009)
T Deyama et al.
Acta pharmacologica Sinica, 22(12), 1057-1070 (2001-12-26)
The bark and leaves of Eucommia ulmoides Oliv (Eucommiaceae) and "Siberian ginseng" (Ezoukogi in Japanese) prepared from the root bark or stem bark of Eleutherococcus senticosus Maxim (Acanthopanax senticosus Harms) have been used as tonic and anti-stress drug. The extracts
Jörg Ziegler et al.
Scientific reports, 7(1), 3704-3704 (2017-06-18)
The chemical composition of root exudates strongly impacts the interactions of plants with microorganisms in the rhizosphere and the efficiency of nutrient acquisition. Exudation of metabolites is in part mediated by ATP-binding cassette (ABC) transporters. In order to assess the
Weiping Wang et al.
Journal of chromatography. A, 1148(1), 108-114 (2007-03-27)
A capillary zone electrophoresis (CZE) with indirect laser-induced fluorescence detection (ILIFD) method is described for the simultaneous determination of esculin, esculetin, isofraxidin, genistein, naringin and sophoricoside. The baseline separation was achieved within 5 min with running buffer (pH 9.4) composed
Hui Sun et al.
Journal of separation science, 30(18), 3120-3126 (2007-11-17)
An HPLC with SPE method has been developed for analysis of constituents in rat blood after oral administration of the extract of Acanthopanax senticosus (ASE). The plasma sample was prepared by SPE method equipped with Oasis HLB cartridge (3cc, 60
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