909947
3-Azido-L-alanine hydrochloride
≥95%
Synonym(s):
(S)-2-Amino-3-azidopropanoic acid hydrochloride, 3-Azido-L-alanine HCl, 3-Azido-L-alanine hydrochloride, H-L-Ala(N3)-OH*HCl, H-L-Aza-OH*HCl, H-L-Dap(N3)-OH*HCl
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About This Item
Empirical Formula (Hill Notation):
C3H6N4O2 · HCl
Molecular Weight:
166.57
UNSPSC Code:
12352209
Product Name
3-Azido-L-alanine hydrochloride, ≥95%
assay
≥95%
form
solid
reaction suitability
reaction type: solution phase peptide synthesis
availability
available only in USA
storage temp.
2-8°C
Application
The in vivo incorporation of clickable unnatural amino acids such as 3-Azido-L-alanine with unique reactivity at a defined postition is used for functionalization of proteins. The azide functionalities in the protein can then be modified with almost any alkyne bearing molecule by Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC). Copper-free alternatives with strained internal alkynes are also available (SPAAC). Some examples enabled with this technique are protein PEGylation, masking with sugars, and the attachment to antibodies.
signalword
Danger
hcodes
Hazard Classifications
Self-react. C
Storage Class
5.2 - Organic peroxides and self-reacting hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Kristi L Kiick et al.
Proceedings of the National Academy of Sciences of the United States of America, 99(1), 19-24 (2001-12-26)
The introduction of chemically unique groups into proteins by means of non-natural amino acids has numerous applications in protein engineering and functional studies. One method to achieve this involves the utilization of a non-natural amino acid by the cell's native
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