90240
Glyceryl triacetate
≥99.0% (GC)
Synonym(s):
1,2,3-Triacetoxypropane, 1,2,3-Triacetylglycerol, Glycerol triacetate, Triacetin
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About This Item
Linear Formula:
(CH3COOCH2)2CHOCOCH3
CAS Number:
Molecular Weight:
218.20
Beilstein:
1792353
EC Number:
MDL number:
UNSPSC Code:
12352211
PubChem Substance ID:
NACRES:
NA.25
Quality Level
Assay
≥99.0% (GC)
form
liquid
refractive index
n20/D 1.431
bp
258-260 °C (lit.)
density
1.158 g/mL at 20 °C
lipid type
saturated FAs
SMILES string
CC(=O)OCC(COC(C)=O)OC(C)=O
InChI
1S/C9H14O6/c1-6(10)13-4-9(15-8(3)12)5-14-7(2)11/h9H,4-5H2,1-3H3
InChI key
URAYPUMNDPQOKB-UHFFFAOYSA-N
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Application
- Epigenetic priming targets tumor heterogeneity to shift transcriptomic phenotype of pancreatic ductal adenocarcinoma towards a Vitamin D susceptible state.: This groundbreaking study utilizes glyceryl triacetate as part of an epigenetic priming strategy to sensitize pancreatic ductal adenocarcinoma to Vitamin D, marking a significant advancement in cancer treatment modalities (He et al., 2024).
- Glyceryl triacetate promotes blood-brain barrier recovery after ischemic stroke through lipogenesis-mediated IL-33 in mice.: Research demonstrates glyceryl triacetate′s effectiveness in enhancing blood-brain barrier repair post-ischemic stroke via lipogenesis pathways, offering insights into novel stroke recovery treatments (Wei et al., 2023).
- Development of A Nanostructured Lipid Carrier-Based Drug Delivery Strategy for Apigenin: Experimental Design Based on CCD-RSM and Evaluation against NSCLC In Vitro.: This study details the formulation of a nanostructured lipid carrier incorporating glyceryl triacetate, optimized for delivering apigenin to combat non-small cell lung cancer, emphasizing the potential of glyceryl triacetate in targeted therapy applications (Wang et al., 2023).
- Are New Phthalate Ester Substitutes Safer than Traditional DBP and DiBP Comparative Endocrine-Disrupting Analyses on Zebrafish Using In Vivo, Transcriptome, and In Silico Approaches.: Investigating glyceryl triacetate as a safer alternative to traditional phthalate esters, this study explores its lower endocrine-disrupting effects, contributing to safer industrial and pharmaceutical applications (Tan et al., 2023).
- Glyceryl triacetate feeding in mice increases plasma acetate levels but has no anticonvulsant effects in acute electrical seizure models.: This research evaluates the biochemical impact of glyceryl triacetate on plasma acetate levels, providing valuable data on its metabolic effects despite a lack of anticonvulsant properties in specific seizure models (Xu et al., 2022).
WGK
WGK 1
Flash Point(F)
298.4 °F
Flash Point(C)
148 °C
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Boyong Wan et al.
Analytica chimica acta, 681(1-2), 63-70 (2010-11-03)
Wavelet analysis is developed as a preprocessing tool for use in removing background information from near-infrared (near-IR) single-beam spectra before the construction of multivariate calibration models. Three data sets collected with three different near-IR spectrometers are investigated that involve the
G Sharma et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 76(2), 159-169 (2010-07-27)
Insulin loaded microemulsions were developed adopting a low shear reverse micellar approach using didoceyldimethylammonium bromide (DMAB) as the surfactant, propylene glycol (PG) as the co-surfactant, triacetin (TA) as the oil phase and insulin solution as the aqueous phase. A ternary
Shanhui Zhu et al.
Bioresource technology, 130, 45-51 (2013-01-12)
The synthesis of bioadditives for biofuels from glycerol esterification with acetic acid was performed over zirconia supported heteropolyacids catalysts using H(4)SiW(12)O(40) (HSiW), H(3)PW(12)O(40) (HPW) and H(3)PMo(12)O(40) (HPMo) as active compounds. The as-prepared catalysts were characterized by N(2)-physisorption, XRD, Raman spectroscopy
C N Madhavarao et al.
Journal of inherited metabolic disease, 32(5), 640-640 (2009-08-18)
Canavan disease (CD) is a fatal dysmyelinating genetic disorder associated with aspartoacylase deficiency, resulting in decreased brain acetate levels and reduced myelin lipid synthesis in the developing brain. Here we tested tolerability of a potent acetate precursor, glyceryl triacetate (GTA)
Hui Liu et al.
Journal of pharmaceutical sciences, 101(5), 1783-1793 (2012-02-10)
Although injectable depot-forming solutions have been commercialized, the factors that influence the overall release kinetics from such systems are still not fully understood. In this work, we address the effect of cosolvent on the issue of excessive burst release of
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