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901989

Sigma-Aldrich

Tetrazine-NHS ester

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Empirical Formula (Hill Notation):
C14H11N5O4
Molecular Weight:
313.27
MDL number:
MFCD29052194
UNSPSC Code:
12352200
NACRES:
NA.22

form

powder

availability

available only in USA

mp

171-177 °C

storage temp.

−20°C

Application

Tetrazine-NHS ester demonstrates exceptionally fast cycloaddition kinetics with trans-cyclooctene (TCO) as the dienophile (up to 30,000 M-1 s-1). These have been the fastest kinetics reported for a bioorthogonal reaction. The chemical stability of tetrazines is substantially lower compared to methyltetrazines, thus requiring more careful selection of reagents and conditions for chemical transformation. However, tetrazine chemistry is still in an acceptable range for many applications.

Pictograms

Flame
GHS02

Signal Word

Danger

Hazard Statements

H242

Hazard Classifications

Self-react. C

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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