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Safety Information

89730

Sigma-Aldrich

p-Toluenesulfonyl chloride

ReagentPlus®, ≥99.0%

Synonym(s):

Tosyl chloride

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About This Item

Linear Formula:
CH3C6H4SO2Cl
CAS Number:
98-59-9
Molecular Weight:
190.65
Beilstein:
607898
EC Number:
202-684-8
MDL number:
MFCD00007450
UNSPSC Code:
12352100
PubChem Substance ID:
329769530

vapor pressure

1 mmHg ( 88 °C)

product line

ReagentPlus®

Assay

≥99.0%

bp

134 °C/10 mmHg (lit.)

mp

65-69 °C (lit.)
66-69 °C

solubility

methylene chloride: 0.2 g/mL, clear
benzene-d6: freely soluble(lit.)
chloroform: freely soluble(lit.)
ethanol: freely soluble(lit.)
water: insoluble(lit.)

SMILES string

CC1=CC(OP(OC)(OC)=S)=CC=C1SC([2H])([2H])[2H]
Cc1ccc(cc1)S(Cl)(=O)=O

InChI

1S/C7H7ClO2S/c1-6-2-4-7(5-3-6)11(8,9)10/h2-5H,1H3

InChI key

YYROPELSRYBVMQ-UHFFFAOYSA-N

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Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H290,H315,H317,H318

Hazard Classifications

Eye Dam. 1 - Met. Corr. 1 - Skin Irrit. 2 - Skin Sens. 1

Storage Class Code

8B - Non-combustible corrosive hazardous materials

WGK

WGK 1

Flash Point(F)

262.4 °F - closed cup

Flash Point(C)

128 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Balázs Pásztói et al.
Polymers, 12(11) (2020-11-01)
Endfunctional polymers possess significant industrial and scientific importance. Sulfonyl endgroups, such as tosyl and nosyl endfunctionalities, due their ease of substitution are highly desired for a variety of polymer structures. The sulfonylation of hydroxyl-terminated polyisobutylene (PIB-OH), a chemically and thermally
p-Toluenesulfonyl Chloride.
Whitaker DT, et al.
e-EROS Encyclopedia of Reagents for Organic Synthesis. (2006)
[Degradation reactions of oral antidiabetics. 2. Reaction of arylsulfonylureas with 4-toluenesulfonyl chloride].
H Egg et al.
Archiv der Pharmazie, 320(3), 253-257 (1987-03-01)
Rince Wong et al.
The Journal of organic chemistry, 72(10), 3969-3971 (2007-04-21)
A facile and general protocol for the preparation of isothiocyanates from alkyl and aryl amines is reported. This method relies on a tosyl chloride mediated decomposition of a dithiocarbamate salt that is generated in situ by treatment of an amine
Y Tabata et al.
Biomaterials, 7(3), 234-238 (1986-05-01)
The cyanogen bromide (CNBr) activation method was adopted to link collagen molecules onto the surface of cellulose and poly(vinyl alcohol) (PVA) films via covalent bonding. The amount of bound protein was determined by the ninhydrin method and found to be
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