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Merck
CN

87472

Hydrogen chloride solution

~3 M in 1-butanol, derivatization grade (GC derivatization), LiChropur™

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About This Item

CAS Number:
7647-01-0
NACRES:
NA.22
PubChem Substance ID:
329769583
UNSPSC Code:
12352301
MDL number:
MFCD00011324
Beilstein/REAXYS Number:
1098214
Concentration:
~3 M in 1-butanol
Form:
solution
Grade:
derivatization grade (GC derivatization)

Key Documents

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Product Name

Hydrogen chloride - 1-butanol solution, ~3 M in 1-butanol, derivatization grade (GC derivatization), LiChropur™

InChI key

VEXZGXHMUGYJMC-UHFFFAOYSA-N

SMILES string

Cl

InChI

1S/ClH/h1H

grade

derivatization grade (GC derivatization)

form

solution

quality

LiChropur™

reaction suitability

reagent type: derivatization reagent
reaction type: Acylations

concentration

~3 M in 1-butanol

technique(s)

gas chromatography (GC): suitable

density

0.87 g/mL at 20 °C

storage temp.

2-8°C

Quality Level

100

Related Categories

General description

Acylation, an alternative to silylation, is the conversion of compounds that contain active hydrogens (-OH, -SH and -NH) into esters, thioesters, and amides through the action of a carboxylic acid or derivative. The presence of a carbonyl group adjacent to the halogenated carbons enhances electron capture detector (ECD) response. Acylation has many benefits:
  • It improves the stability of compounds by protecting unstable groups.
  • It may confer volatility on substances such as carbohydrates or amino acids, which have so many polar groups that they are non-volatile and normally decompose on heating.
  • It assists in separations not possible with underivatized compounds.
  • Compounds are detectable at very low levels with an ECD.

Hydrogen chloride-1-butanol is a reagent utilized to form fragmentation-directing derivatives for GC/MS analysis.

Application

Hydrogen chloride - 1-butanol solution has been used for butylation of amino acids during blood sample analysis for determination of ethylenediaminetetraacetic acid using mass spectrometry.

Other Notes

Reagent for the esterification of amino acids and carnites for GC-MS analysis.

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Met. Corr. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

3 - Flammable liquids

wgk

WGK 1

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Regulatory Information

危险化学品
易制毒化学品（3类）
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Certificates of Analysis (COA)

Lot/Batch Number
BCCN3119
BCCL8269
BCCJ6881
BCCG8459
BCCF1421

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M S Rashed et al.
Clinical chemistry, 43(7), 1129-1141 (1997-07-01)
Metabolic profiling of amino acids and acylcarnitines from blood spots by automated electrospray tandem mass spectrometry (ESI-MS/MS) is a powerful diagnostic tool for inborn errors of metabolism. New approaches to sample preparation and data interpretation have helped establish the methodology
Akihiro Hideno et al.
Bioresource technology, 132, 64-70 (2013-02-12)
The effects of adding trace acids in ethanol based organosolv treatment were investigated to increase the enzymatic digestibility of Japanese cypress. A high glucose yield (60%) in the enzymatic hydrolysis was obtained by treating the sample at 170 °C for
Daniely Cornélio Favarin et al.
Mediators of inflammation, 2013, 164202-164202 (2013-03-28)
Acute lung injury (ALI) is characterized by alveolar edema and uncontrolled neutrophil migration to the lung, and no specific therapy is still available. Ellagic acid, a compound present in several fruits and medicinal plants, has shown anti-inflammatory activity in several
Yan-Ling Li et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(6), 817-820 (2013-05-31)
To prepare the new traditional Chinese medicine preparation--pH-dependent brevisapin colon-specific tablets, and investigate its in vitro release, in order to discuss the feasibility of preparing colon-targeted traditional Chinese medicines. With scutellarin, the active ingredient in brevisapin, as the evaluation index
Q Miao et al.
Physical review letters, 109(23), 233905-233905 (2013-02-02)
X-ray lasing is predicted to ensue when molecules are pumped into dissociative core-excited states by a free-electron-laser pulse. The lasing is due to the population inversion created in the neutral dissociation product, and the process features self-trapping of the x-ray
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Analysis of Acylcarnitines in Dried Blood Spots (DBS) Samples by FIA-MS/MS

In this article we provide a complete workflow of quantification and identification of acylcarnitines in dried blood spots (DBS) using stable isotope-labeled (SIL) acylcarnitines CRMs by FIA-MS/MS.

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