861405
Hoechst 33258
Synonym(s):
2′-(4-hydroxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5′-bi-1H-benzimidazole trihydrochloride hydrate, bisBenzimide
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About This Item
Empirical Formula (Hill Notation):
C25H24N6O · 3HCl · xH2O
CAS Number:
Molecular Weight:
533.88 (anhydrous basis)
EC Number:
MDL number:
UNSPSC Code:
12171500
PubChem Substance ID:
Recommended Products
Assay
≥98% (TLC)
form
powder
mp
>300 °C (lit.)
λmax
343 nm
SMILES string
Cl[H].Cl[H].Cl[H].[H]O[H].CN1CCN(CC1)c2ccc3[nH]c(nc3c2)-c4ccc5[nH]c(nc5c4)-c6ccc(O)cc6
Other Notes
This product has been replaced by B2883-Sigma-Aldrich | bisBenzimide H 33258 ≥98% (HPLC and TLC)
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Shawn N Whitehead et al.
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Pro-atherogenic and pro-oxidant, oxidised LDL trigger adverse effects on pancreatic beta cells, possibly contributing to diabetes progression. Because oxidised LDL diminish the expression of genes regulated by the inducible cAMP early repressor (ICER), we investigated the involvement of this transcription
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Endoreplicating cells undergo multiple rounds of DNA replication leading to polyploidy or polyteny. Oscillation of Cyclin E (CycE)-dependent kinase activity is the main driving force in Drosophila endocycles. High levels of CycE-Cdk2 activity trigger S phase, while down-regulation of CycE-Cdk2
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