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Merck
CN

85549

Span® 85

Synonym(s):

Sorbitan trioleate, Span® 85

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About This Item

Empirical Formula (Hill Notation):
C60H108O8
CAS Number:
26266-58-0
Molecular Weight:
957.49
UNSPSC Code:
12161900
PubChem Substance ID:
24888385
EC Number:
247-569-3
MDL number:
MFCD00133820

Key Documents

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InChI key

ZBNRGEMZNWHCGA-WECPCUOASA-N

InChI

1S/C60H108O8/c1-4-7-10-13-16-19-22-25-28-31-34-37-40-43-46-49-56(62)65-52-54(61)59-60(68-58(64)51-48-45-42-39-36-33-30-27-24-21-18-15-12-9-6-3)55(53-66-59)67-57(63)50-47-44-41-38-35-32-29-26-23-20-17-14-11-8-5-2/h25-30,54-55,59-61H,4-24,31-53H2,1-3H3/b28-25-,29-26-,30-27+/t54-,55+,59-,60-/m1/s1

SMILES string

CCCCCCCC\C=C/CCCCCCCC(=O)O[C@H](CO)[C@H]1OC[C@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC

description

non-ionic

refractive index

n20/D 1.476 (lit.)

viscosity

200-300 mPa.s(20 °C)

HLB value

1.8±1.1

density

0.94 g/mL at 20 °C, 0.956 g/mL at 25 °C (lit.)

Legal Information

Span is a registered trademark of Croda International PLC

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

437.0 °F

flash_point_c

225 °C

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Information

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Gülay Büyükköroğlu et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 109, 174-183 (2016-10-30)
Cervical cancer is one of the most life threatening types of cancer among women and is generally resistant to chemotherapy. The objective of this study was to prepare a vaginal suppository containing a chemotherapeutic agent and a genetic material that
A N Hassan et al.
International journal of food microbiology, 87(1-2), 145-152 (2003-08-21)
The influence of surfactant hydrophobicity on detachment of Escherichia coli O157:H7 from lettuce was determined. Lettuce pieces inoculated with the pathogen were rinsed with Tween and Span surfactants of different hydrophobicity. Of the Tweens, only Tween 85, the Tween with
Maik J Geerken et al.
Journal of colloid and interface science, 312(2), 460-469 (2007-05-08)
The formation of emulsions with micro-engineered silicon based arrays of micro-orifices is a relatively new technique. Until now, only the preparation of oil-in-water emulsions was studied due to the hydrophilic nature of silicon. This work evaluates the emulsification of water
Hiroaki Todo et al.
International journal of pharmaceutics, 271(1-2), 41-52 (2004-05-08)
The effect of pulmonary absorption enhancers on the stability of active ingredients is an important factor for successful inhalation therapy as well as the effect on pharmacological activity and safety. We examined the effect of pulmonary absorption enhancers on the
P M Blackett et al.
Pharmaceutical research, 12(11), 1689-1693 (1995-11-01)
The purpose of the work is to study the adsorption of Oleic acid and Span 85 (materials frequently used in aerosols as surfactants) onto partially amorphous and essentially crystalline salbutamol sulphate, attempting to understand the behaviour of metered dose inhalers
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