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85431

Supelco

Silylating mixture I according to Sweeley

for GC derivatization, LiChropur

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Synonym(s):
Chlorotrimethylsilane – hexamethyldisilazane mixture, Sylon HTP, hexamethyldisilazane/chlorotrimethylsilane/pyridine = 2:1:10 (v/v/v), HMDS + TMCS
CAS Number:
MDL number:
UNSPSC Code:
12000000
PubChem Substance ID:
NACRES:
NA.22

grade

for GC derivatization

Quality Level

description

ready to use solution in pyridine (10 vol parts)

form

liquid

quality

LiChropur

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

technique(s)

gas chromatography (GC): suitable

storage temp.

2-8°C

SMILES string

C[Si](C)(C)Cl.C[Si](C)(C)N[Si](C)(C)C.C[Si](C)(C)N[Si](C)(C)C

InChI

1S/2C6H19NSi2.C3H9ClSi/c2*1-8(2,3)7-9(4,5)6;1-5(2,3)4/h2*7H,1-6H3;1-3H3

InChI key

UCJNZOHHMSKSRP-UHFFFAOYSA-N

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Application

Learn more in the Product Information

Components

hexamethyldisilazane : chlorotrimethylsilane : pyridine = 2:1:10 (v/v)

Other Notes

Useful silylating mixture for the silylation of hydroxy-compounds

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany
Sylon is a trademark of Sigma-Aldrich Co. LLC

related product

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B

WGK

WGK 2

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

危险化学品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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J. Heberle et al.
Silylating Agents, 2nd ed. (1995)
Sweeley, C.C., et al.
Journal of the American Chemical Society, 85, 2497-2497 (1963)

Articles

Results of a study involving the ability few Fluka silylating reagents to form GC-MS-compatible trimethylsilylmethyl derivatives of NSAIDs

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