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Safety Information

84480

Sigma-Aldrich

Sanguinarine chloride

≥98.0% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C20H14ClNO4
CAS Number:
Molecular Weight:
367.78
Beilstein:
3832138
MDL number:
UNSPSC Code:
12352203

Assay

≥98.0% (HPLC)

solubility

methanol: 20 mg/mL, clear, orange

SMILES string

[Cl-].C[n+]1cc2c3OCOc3ccc2c4ccc5cc6OCOc6cc5c14

InChI

1S/C20H14NO4.ClH/c1-21-8-15-12(4-5-16-20(15)25-10-22-16)13-3-2-11-6-17-18(24-9-23-17)7-14(11)19(13)21;/h2-8H,9-10H2,1H3;1H/q+1;/p-1

InChI key

GIZKAXHWLRYMLE-UHFFFAOYSA-M

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Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 2 Oral

Storage Class Code

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Haowei Li et al.
Biochemical and biophysical research communications, 430(3), 951-956 (2012-12-25)
Sanguinarine is a natural plant extract that has been supplemented in a number of gingival health products to suppress the growth of dental plaque. However, whether sanguinarine has any effect on teeth and alveolar bone health is still unclear. In
Priya Weerasinghe et al.
Experimental and molecular pathology, 93(3), 302-308 (2012-10-06)
It is now increasingly accepted that apoptosis may not be the only form of cell death seen in vitro and in vivo; hence there is a need to study novel forms of cell death. The explosion of cell death research
Xiaofeng Niu et al.
European journal of pharmacology, 689(1-3), 262-269 (2012-06-19)
The quaternary ammonium salt, sanguinarine (SANG), is of great practical and research interest because of its pronounced, widespread physiological effects, which promote anti-microbial and anti-inflammatory responses in experimental animals. Sanguinarine was originally shown to possess anti-inflammatory properties and it has
Xiaofeng Niu et al.
Toxicology and applied pharmacology, 267(3), 256-265 (2013-01-29)
The quaternary ammonium salt, sanguinarine (SANG), is of great practical and research interest because of its pronounced, widespread physiological effects, which promote anti-microbial and anti-inflammatory responses in experimental animals. Although SANG is originally shown to possess anti-inflammatory properties and it
Naveen Bojjireddy et al.
Archives of biochemistry and biophysics, 537(2), 192-197 (2013-08-01)
The effects of sanguinarine on IgE mediated early signaling mechanisms leading to inflammatory mediators release were investigated. Pretreatment of RBL 2H3 cells with sanguinarine inhibited IgE induced activation of type II PtdIns 4-kinase activity. Concomitant with type II PtdIns 4-kinase

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