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80693

Supelco

(±)-2-Propyl-4-pentenoic acid

analytical standard

Synonym(s):

2-Allylpentanoic acid

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About This Item

Empirical Formula (Hill Notation):
C8H14O2
CAS Number:
1575-72-0
Molecular Weight:
142.20
Beilstein:
1704069
MDL number:
MFCD00869309
UNSPSC Code:
41116107
PubChem Substance ID:
329769036
NACRES:
NA.24

grade

analytical standard

Quality Level

100

Assay

≥97.0% (GC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical

format

neat

storage temp.

2-8°C

SMILES string

C=CCC(CCC)C(O)=O

InChI

1S/C8H14O2/c1-3-5-7(6-4-2)8(9)10/h3,7H,1,4-6H2,2H3,(H,9,10)

InChI key

UMYDNZXEHYSVFY-UHFFFAOYSA-N

General description

2-Propyl-4-pentenoic acid is the main teratogenic and hepatotoxic metabolite of valproic acid, an anticonvulsant prescribed for treating seizures and for the maintenance phase of bipolar disorders.

Application

2-Propyl-4-pentenoic acid may be used as an analytical standard for the determination of the analyte in biological samples by various chromatography-based techniques.

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Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Precautionary Statements

P301 + P310

Hazard Classifications

Acute Tox. 3 Oral

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Quantification of valproic acid and its metabolite 2-propyl-4-pentenoic acid in human plasma using HPLC-MS/MS
Cheng H, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 850(1-2), 206-212 (2007)
Prophylactic efficacy of lithium, valproic acid, and carbamazepine in the maintenance phase of bipolar disorder: a naturalistic study
Peselow ED, et al.
International Clinical Psychopharmacology, 31(4), 218-223 (2016)
Cheng Chang et al.
Molecular pharmacology, 94(2), 823-833 (2018-06-02)
Kynurenic acid (KYNA) plays a significant role in maintaining normal brain function, and abnormalities in KYNA levels have been associated with various central nervous system disorders. Confirmation of its causality in human diseases requires safe and effective modulation of central
Zhuo-Jia Chen et al.
Seizure, 21(2), 110-117 (2011-11-08)
Valproic acid (VPA) is a well-established anticonvulsant drug that has been increasingly used in the treatment of many forms of generalized epilepsy. Although there are many reports of adverse effects of VPA, studies focusing on the concentration-response relationships of VPA
Wojciech Jawień et al.
Pharmacological reports : PR, 69(2), 340-349 (2017-02-12)
Valproic acid (VPA) is a first-line antiepileptic drug. It is used in the treatment of many different types of partial and generalized epileptic seizures. Though the clinical pharmacokinetics of VPA has been well defined, information about pharmacokinetics after overdoses is
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