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Merck
CN

791962

Cyclopentyl methyl ether

greener alternative

inhibitor-free, anhydrous, ≥99.9%

Synonym(s):

CMPE, CPME

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About This Item

Empirical Formula (Hill Notation):
C6H12O
CAS Number:
5614-37-9
Molecular Weight:
100.16
NACRES:
NA.21
PubChem Substance ID:
329768304
UNSPSC Code:
12352112
MDL number:
MFCD08276401
Grade:
anhydrous
Assay:
≥99.9%
Bp:
106 °C/760 mmHg

Key Documents

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Product Name

Cyclopentyl methyl ether, inhibitor-free, anhydrous, ≥99.9%

InChI

1S/C6H12O/c1-7-6-4-2-3-5-6/h6H,2-5H2,1H3

SMILES string

COC1CCCC1

InChI key

SKTCDJAMAYNROS-UHFFFAOYSA-N

grade

anhydrous

assay

≥99.9%

form

liquid

greener alternative product characteristics

Safer Solvents and Auxiliaries
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

impurities

≤0.0050% water
water

bp

106 °C/760 mmHg

mp

-140 °C (lit.)

density

0.86 g/mL at 25 °C

greener alternative category

, Aligned

Quality Level

100

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Application

  • Cyclopentyl methyl ether (CPME) is an alternative to ether solvents such as THF, diethyl ether, and MTBE with a higher resistance to peroxide formation.
  • The more environmentally conservative CPME solvent replaces hazardous solvents in order to achieve sustainability and reduce environmental and operational costs.
  • CPME offers considerable potential and advantage as a direct replacement for CH2Cl2 in binary eluents using MeOH as the modifier with MeOH–DMC and i-PrOH–EtOAc.

Features and Benefits

Greener alternative for THF, diethyl ether, and MTBE

General description

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. Cyclopentyl methyl ether (CPME) is a greener alternative to other ethereal solvents such as tetrahydrofuran (THF), 2-methyl tetrahydrofuran (2-MeTHF), dioxane (carcinogenic), tert-Butyl methyl ether (MTBE), and 1,2-dimethoxyethane (DME) and thus has been enhanced for "Safer Solvents and Auxiliaries". Click here for more information.

Other Notes

The Toxicological Assessment of Cyclopentyl Methyl Ether (CPME) as a Green Solvent

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

<37.4 °F - closed cup

flash_point_c

< 3 °C - closed cup

Regulatory Information

危险化学品
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Certificates of Analysis (COA)

Lot/Batch Number
SHBS7362
SHBQ8311
SHBQ6771
SHBQ3729
SHBP8687

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Watanabe, K.;
Organic Process Research & Development, 11 (2007)
MacMillan, D. S. ;
Green Chemistry (2012)
Rikako Takahiro et al.
Biological & pharmaceutical bulletin, 38(1), 58-65 (2015-03-07)
The aim of this study was to characterize the kinetics of metabolite formation of the phosphodiesterase type-5 (PDE5) inhibitors sildenafil and tadalafil by CYP3A4, CYP3A5, and CYP3A7 isoforms. The formations of N-desmethyl sildenafil and desmethylene tadalafil were examined using CYP3A

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