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76886

Sigma-Aldrich

Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride complex

for fluorescence

Synonym(s):

Ru(ddp)

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About This Item

Empirical Formula (Hill Notation):
C72H48Cl2N6Ru
CAS Number:
36309-88-3
Molecular Weight:
1169.17
MDL number:
MFCD03095387
UNSPSC Code:
12352103
PubChem Substance ID:
329767411

grade

for fluorescence

Assay

≥95% (HPCE)

form

powder

solubility

DMF: soluble
chloroform: soluble
ethanol: soluble
methanol: soluble

fluorescence

λex 455 nm; λem 610-630 nm in 0.1 M phosphate pH 7.0

SMILES string

Cl[Ru]Cl.c1ccc(cc1)-c2ccnc3c2ccc4c(ccnc34)-c5ccccc5.c6ccc(cc6)-c7ccnc8c7ccc9c(ccnc89)-c%10ccccc%10.c%11ccc(cc%11)-c%12ccnc%13c%12ccc%14c(ccnc%13%14)-c%15ccccc%15

InChI

1S/3C24H16N2.2ClH.Ru/c3*1-3-7-17(8-4-1)19-13-15-25-23-21(19)11-12-22-20(14-16-26-24(22)23)18-9-5-2-6-10-18;;;/h3*1-16H;2*1H;/q;;;;;+2/p-2

InChI key

SKZWFYFFTOHWQP-UHFFFAOYSA-L

Application

Ruthenium-tris(4,7-diphenyl-1,10-phenanthroline) dichloride (Ru(dpp)) has been widely used as a probe for luminescent detection and quantitation of oxygen. The fluorescence of the dye (abs. λmax 455 nm, luminescence λmax 613 nm) is strongly reduced by molecular oxygen due to dynamic quenching, making Ru(dpp) a viable oxygen probe based on either measurement of intensity or decay time. Ru(ddp) has been used for fiber optic sensors, studies on oxygen in skin and skin tumors, measurement of oxygen flux through skin, and for oxygen imaging.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is the appearance of Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride complex (Rubidium-tris), Product 76886, supposed to be?

    Product No. 76886 is an orange solid.

  4. What are some applications for Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride complex (Rubidium-tris), Product 76886?

    This product is widely used 1) as a probe for luminescent detection, 2) for quantitation of oxygen using (fiber) optic sensors[1,2], 3) studies on oxygen in skin [3,4].

  5. In what solvents is Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride complex (Rubidium-tris), Product 76886, soluble?

    It is soluble in DMF, chloroform, ethanol, methanol and toluene (moderately).

  6. Do you have any information on the optical properties of the dye commonly known as Ru(dpp), Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride complex (Rubidium-tris), Product 76886?

    We have the following information regarding solutions of this dye in toluene. The absorbance (excitation) maximum is at 455 nm, with a fluorescence (emission) maximum of 613 nm. The extinction coefficient of the visible maximum (~460 nm) is 30,000 M-1cm-1.

  7. What is the O2 detection/determination limit of Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride complex (Rubidium-tris), Product 76886?

    Unfortunately, we currently do not have such information available. Generally, this sensor dye's oxygen detection is based on quenching of its luminescence by oxygen. Its detection limit for oxygen in solution will be mainly depending on the intensity differences the used fluorimeter can detect.

  8. What can be used with Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride complex (Rubidium-tris), Product 76886, for the fabrication of O2 sensor layers?

    According to what we have found in the literature, asilicone polymer and polystyrene have both been used for sensor fabrication. See Klimant, I. and O.S. Wolfbeis, Analytical Chemistry, 67, 3160-3166 (1995) and references cited therein.

  9. What are the recommended storage conditions for Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride complex (Rubidium-tris), Product 76886?

    We recommend that this product be stored under an inert gas, such as argon. Avoid light, because it is light-sensitive.

  10. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  11. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  12. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

W L Rumsey et al.
Science (New York, N.Y.), 241(4873), 1649-1651 (1988-09-23)
The imaging of phosphorescence provides a method for monitoring oxygen distribution within the vascular system of intact tissues. Isolated rat lives were perfused through the portal vein with media containing palladium coproporphyrin, which phosphoresced and was used to image the
G. Liebsch et al.
Appl. Spectroscopy, 54, 548-548 (2000)
Federica Tonon et al.
Scientific reports, 9(1), 13557-13557 (2019-09-21)
Among the multiple metabolic signals involved in the establishment of the hepatic zonation, oxygen could play a key role. Indeed, depending on hepatocyte position in the hepatic lobule, gene expression and metabolism are differently affected by the oxygen gradient present
Yuta Ando et al.
Advanced healthcare materials, 8(5), e1900001-e1900001 (2019-02-09)
Despite its revolutionary success in hematological malignancies, chimeric antigen receptor T (CAR-T) cell therapy faces disappointing clinical results in solid tumors. The poor efficacy has been partially attributed to the lack of understanding in how CAR-T cells function in a
Yuta Ando et al.
Scientific reports, 7(1), 15233-15233 (2017-11-11)
Hypoxia plays a central role in cancer progression and resistance to therapy. We have engineered a microdevice platform to recapitulate the intratumor oxygen gradients that drive the heterogeneous hypoxic landscapes in solid tumors. Our design features a "tumor section"-like culture
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