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Synephrine

analytical standard

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Synonym(s):
1-(4-Hydroxyphenyl)-2-methylaminoethanol, 4-Hydroxy-α-(methylaminomethyl)benzyl alcohol
Empirical Formula (Hill Notation):
C9H13NO2
CAS Number:
94-07-5
Molecular Weight:
167.21
EC Number:
202-300-9
MDL number:
MFCD00002370
UNSPSC Code:
85151701
PubChem Substance ID:
329766291
NACRES:
NA.24

grade

analytical standard

Assay

≥98.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

impurities

≤12.0% water (Karl Fischer)

application(s)

food and beverages

format

neat

storage temp.

2-8°C

InChI

1S/C9H13NO2/c1-10-6-9(12)7-2-4-8(11)5-3-7/h2-5,9-12H,6H2,1H3

InChI key

YRCWQPVGYLYSOX-UHFFFAOYSA-N

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General description

Synephrine is a sympathomimetic amine from the plant Citrus aurantium and is identified as a major active component of dietary supplements.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Synephrine may be used as a reference standard for the determination of synephrine in dietary supplements using high-performance liquid chromatography with acidic potassium permanganate chemiluminescence detection.

Analysis Note

identification (GC-MS): identity conforms

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ischemic stroke associated with use of an ephedra-free dietary supplement containing synephrine.
Bouchard CN, et al.
Mayo Clinic Proceedings. Mayo Clinic, 80(4), 541-545 (2005)
Determination of synephrine in weight-loss products using high performance liquid chromatography with acidic potassium permanganate chemiluminescence detection.
Slezak T, et al.
Analytica Chimica Acta, 593(1), 98-102 (2007)
Sidney J Stohs et al.
International journal of medical sciences, 9(7), 527-538 (2012-09-20)
This review summarizes the published as well as unpublished human studies involving Citrus aurantium (bitter orange) extract and its primary protoalkaloid p-synephrine, providing information and an assessment of the safety and efficacy of these widely used products. The results of
Sidney J Stohs et al.
Phytotherapy research : PTR, 25(10), 1421-1428 (2011-04-12)
Citrus aurantium (bitter orange) extract and its principal protoalkaloidal constituent p-synephrine are widely used in weight loss and weight management as well as in sports performance products. However, questions are raised frequently regarding the safety of these ingredients. The potential
John E Thomas et al.
Texas Heart Institute journal, 36(6), 586-590 (2010-01-14)
Billions of dollars are spent annually in the United States in the largely unregulated market of dietary supplements. Many of these supplements are marketed as weight-loss and athletic-performance-enhancement products. The association of various ephedra-containing products with adverse cardiovascular events has
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