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Merck
CN

75047

Piperine

analytical standard

Synonym(s):

1-Piperoylpiperidine

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About This Item

Empirical Formula (Hill Notation):
C17H19NO3
CAS Number:
94-62-2
Molecular Weight:
285.34
UNSPSC Code:
85151701
NACRES:
NA.24
PubChem Substance ID:
329766089
EC Number:
202-348-0
Beilstein/REAXYS Number:
90741
MDL number:
MFCD00005839

Key Documents

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Product Name

Piperine, analytical standard

InChI

1S/C17H19NO3/c19-17(18-10-4-1-5-11-18)7-3-2-6-14-8-9-15-16(12-14)21-13-20-15/h2-3,6-9,12H,1,4-5,10-11,13H2/b6-2+,7-3+

SMILES string

O=C(\C=C\C=C\c1ccc2OCOc2c1)N3CCCCC3

InChI key

MXXWOMGUGJBKIW-YPCIICBESA-N

grade

analytical standard

assay

≥97.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

131-135 °C (lit.)

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care

format

neat

storage temp.

2-8°C

Quality Level

100

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Application

Piperine may be used as an analytical reference standard for the quantification of the analyte in:
  • Human plasma using high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS).
  • Piper nigrum extract using reversed phase high pressure liquid chromatographic method with UV detection (RP-HPLC-UV).
  • Food products using high-performance liquid chromatography with diode array detection (HPLC-DAD).

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

General description

Piperine is a naturally occurring bioactive alkaloid in pepper, which imparts pungency and bitter flavor to it. It has demonstrated health benefits and exhibits therapeutic properties, which include its role as an antimicrobial, antioxidant, antifungal, immunomodulatory and hepatoprotective agent. The inhibition of drug-metabolizing enzymes in hepatic and pulmonary tissues, and the enhancement of drug bioavailability by this compound are reported. It is also found to play an important role in reducing blood glucose, cholesterol and triglycerides.
Piperine is an amide isolated from the plant, Piper longum. It is a known inhibitor of hepatic and intestinal glucuronidation. Piperine is found to exhibit pharmacological properties like antitumor, antipyretic and anti-inflammatory activities.

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

hcodes

H302,H411

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
BCCL3993
BCCG9128
BCCB4304
BCBV0655

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Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers
Shoba G, et al.
Planta Medica, 64(04), 353- 356 (1998)
Immunomodulatory and antitumor activity of Piper longum Linn. and piperine
Sunila.S.E and Kuttan.G
Journal of Ethnopharmacology, 90(2), 339- 346 (2004)
A liquid chromatography method for the simultaneous determination of curcumin and piperine in food products using diode array detection
Nagappan VK , et al.
Asian Journal of Research in Chemistry, 2(2), 115-118 (2009)
Preliminary study on inhibition of genotoxicity by piperine in mice
Selvendiran K, et al.
Fitoterapia, 76(3-4), 296-300 (2005)
Validated HPLC?MS/MS method for simultaneous determination of curcumin and piperine in human plasma
Wang M-X, et al.
Tropical Journal of Pharmaceutical Research, 11(4), 621-629 (2012)
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