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Iohexol

analytical standard

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Synonym(s):
5-[N-(2,3-Dihydroxypropyl)acetamido]-2,4,6-triiodo-N,N′-bis(2,3-dihydroxypropyl)isophthalamide
Empirical Formula (Hill Notation):
C19H26I3N3O9
CAS Number:
66108-95-0
Molecular Weight:
821.14
Beilstein:
2406632
EC Number:
266-164-2
MDL number:
MFCD00077732
UNSPSC Code:
41116107
PubChem Substance ID:
329765500
NACRES:
NA.24

grade

analytical standard

Quality Level

100

Assay

≥95.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

impurities

≤6.0% water

application(s)

clinical testing

format

neat

SMILES string

IC1=C(C(NCC(O)CO)=O)C(I)=C(C(NCC(CO)O)=O)C(I)=C1N(CC(CO)O)C(C)=O

InChI

1S/C19H26I3N3O9/c1-8(29)25(4-11(32)7-28)17-15(21)12(18(33)23-2-9(30)5-26)14(20)13(16(17)22)19(34)24-3-10(31)6-27/h9-11,26-28,30-32H,2-7H2,1H3,(H,23,33)(H,24,34)

InChI key

NTHXOOBQLCIOLC-UHFFFAOYSA-N

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General description

Iohexol is a non-ionic, water-soluble contrast agent used as a reference marker to determine the glomerular filtration rate (GFR) which measures the level of kidney function. It finds applications in angiographic and urography procedures.

Application

Iohexol may be used as an internal standard for the determination of iohexol in human plasma, serum and urine samples by HPLC-UV method. It may also be used as a model compound to analyze the applicability of iohexol for glomerular filtration rate (GFR) measurement by the plasma clearance of iohexol in investigating renal failure.
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WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Development and validation of an HPLC-UV method for determination of iohexol in human plasma.
Soman R S, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 816(1-2), 339-343 (2005)
Human pharmacokinetics of iohexol. A new nonionic contrast medium.
BO, et al.
Investigative Radiology, 18(2), 177-182 (1983)
Performance of iohexol determination in serum and urine by HPLC: validation, risk and uncertainty assessment.
Cavalier E, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 396(1-2), 80-85 (2008)
Iohexol clearance for GFR-determination in renal failure?single or multiple plasma sampling?.
Sterner G, et al.
Nephrology, Dialysis, and Transplantation, 11(3), 521-525 (1996)
E Van de Kelft et al.
Neurosurgery, 28(4), 570-574 (1991-04-01)
Intracranial hemorrhage is an uncommon complication of dural puncture. In most instances, hematomas are subdural; they may be unilateral or bilateral. Rarely are intraparenchymal cerebral hemorrhages related to dural puncture. This report describes a delayed occurrence of bilateral intraparenchymal hemorrhages
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