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69864

Sigma-Aldrich

Monensin sodium salt

~90% (TLC)

Synonym(s):

Monensin A sodium salt

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About This Item

Empirical Formula (Hill Notation):
C36H61NaO11
CAS Number:
22373-78-0
Molecular Weight:
692.85
Beilstein:
4122200
EC Number:
244-941-7
MDL number:
MFCD00077826
UNSPSC Code:
12352203
PubChem Substance ID:
24885987

Assay

~90% (TLC)

optical activity

[α]20/D +61±2°, c = 1% in DMF

storage temp.

2-8°C

SMILES string

[H][C@]1([C@@]2(CC)O[C@]([C@@]3(C)OC4(C[C@H](O)[C@@H](C)[C@@]([H])([C@@H](C)[C@@H](OC)[C@@H](C([O-])=O)C)O4)CC3)([H])CC2)[C@@H](C)C[C@]([H])([C@@]5([H])O[C@@](O)(CO)[C@H](C)C[C@@H]5C)O1.[Na+]

InChI

1S/C36H62O11.Na/c1-10-34(31-20(3)16-26(43-31)28-19(2)15-21(4)36(41,18-37)46-28)12-11-27(44-34)33(8)13-14-35(47-33)17-25(38)22(5)30(45-35)23(6)29(42-9)24(7)32(39)40;/h19-31,37-38,41H,10-18H2,1-9H3,(H,39,40);/q;+1/p-1/t19-,20-,21+,22+,23-,24-,25-,26+,27+,28-,29+,30-,31+,33-,34-,35?,36-;/m0./s1

InChI key

XOIQMTLWECTKJL-BEMBKCOJSA-M

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General description

Chemical structure: polyether

Other Notes

Monensin - a perturbant of cellular physiology; Forms stable complexes with monovalent cations, thus rendering those ions soluble in organic solvents, review; Transport of monovalent cations across specific biological membranes and liquid membranes; Can be used in a specific ion electrode, and to concentrate solutes against their concentration gradients.; In studies on a sodium ion gradient, as energy source for Peptostreptococcus asaccharolyticus

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Product No.
Description
Pricing

Signal Word

Danger

Hazard Statements

H300,H319,H373,H411

Hazard Classifications

Acute Tox. 2 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - STOT RE 2

Target Organs

Heart,muscle

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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P.W. Ledger et al.
Trends in Biochemical Sciences, 9, 313-313 (1984)
G Wohlfarth et al.
Archives of microbiology, 142(2), 128-135 (1985-07-01)
The determination of enzymatic activities in cell-free extracts of Acidaminococcus fermentans and Peptostreptococcus asaccharolyticus led to a refined scheme for the pathway of glutamate fermentation via (R)-2-hydroxyglutarate to acetate and butyrate. From the ratio of these products the amount of
R Sandeaux et al.
Biochimica et biophysica acta, 684(1), 127-132 (1982-01-04)
Transmembrane 22Na fluxes across bimolecular lipid membranes are measured under two different experimental conditions: (a) the pH is the same in the two bulk aqueous solutions on either side of the membrane while the concentrations of Na+ are different; (b)
G.R. Painter
Metal Ions in Biological Systems, 19, 229-229 (1985)
J L Ellis et al.
Journal of animal science, 90(8), 2717-2726 (2012-08-17)
Monensin is a common feed additive used in various countries, where 1 of the associated benefits for use in beef cattle is improved efficiency of energy metabolism by the rumen bacteria, the animal, or both. Modeling fermentation-altering supplements is of
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