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Ranitidine N-oxide

analytical standard

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Synonym(s):
N-{2-{{{5-[(Dimethyloxidoamino)methyl]-2-furanyl}methyl}thio}ethyl}-N′-methyl-2-nitro-1,1-ethenediamine
Empirical Formula (Hill Notation):
C13H22N4O4S
CAS Number:
73857-20-2
Molecular Weight:
330.40
Beilstein:
8395193
UNSPSC Code:
41116107
NACRES:
NA.24

grade

analytical standard

Quality Level

100

Assay

≥95.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

impurities

≤10.0% water (calc. from elemental analysis)

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CN/C(NCCSCC1=CC=C(CN(C)C)O1)=C\[N+]([O-])=O.O

InChI

1S/C13H22N4O4S/c1-14-13(8-16(18)19)15-6-7-22-10-12-5-4-11(21-12)9-17(2,3)20/h4-5,8,14-15H,6-7,9-10H2,1-3H3/b13-8+

InChI key

DFJVUWAHTQPQCV-MDWZMJQESA-N

Related Categories

General description

Ranitidine N-oxide is a metabolite of the histamine antagonist drug ranitidine, which is prescribed for the treatment of duodenal and gastric ulcers.

Application

Ranitidine N-oxide may be used as an analytical reference standard for the determination of the analyte in biological fluids by high-performance liquid chromatography based technique.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Simple and universal HPLC-UV method to determine cimetidine, ranitidine, famotidine and nizatidine in urine: Application to the analysis of ranitidine and its metabolites in human volunteers
Ashiru, Diane AI , et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 860(2), 235-240 (2007)
High-performance liquid chromatographic methods for the determination of ranitidine and its metabolites in biological fluids
Carey PF, et al.
Chromatographia, 19(1), 200-205 (1984)
M S Lant et al.
Journal of chromatography, 323(1), 143-152 (1985-04-17)
Reversed-phase high-performance liquid chromatography systems for the separation of ranitidine and its metabolites ranitidine-N-oxide, ranitidine-S-oxide, and desmethylranitidine have been developed for use in high-performance liquid chromatography-mass spectrometry. A direct liquid introduction-high-performance liquid chromatography-mass spectrometry system to analyse qualitatively and quantitatively
Determination of ranitidine and its metabolites in human urine by reversed-phase ion-pair high-performance liquid chromatography
Carey PF, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 225(1), 161-168 (1981)

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