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Merck
CN

68909

Sennoside A

analytical standard

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About This Item

Empirical Formula (Hill Notation):
C42H38O20
CAS Number:
81-27-6
Molecular Weight:
862.74
UNSPSC Code:
85151701
NACRES:
NA.24
PubChem Substance ID:
329761216
EC Number:
201-339-9
Beilstein/REAXYS Number:
5723746
MDL number:
MFCD00151527

Key Documents

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InChI key

IPQVTOJGNYVQEO-GTCVFCFLSA-N

InChI

1S/C42H38O20/c43-11-23-31(47)35(51)37(53)41(61-23)59-21-5-1-3-15-25(17-7-13(39(55)56)9-19(45)27(17)33(49)29(15)21)26-16-4-2-6-22(60-42-38(54)36(52)32(48)24(12-44)62-42)30(16)34(50)28-18(26)8-14(40(57)58)10-20(28)46/h1-10,23-26,31-32,35-38,41-48,51-54H,11-12H2,(H,55,56)(H,57,58)/t23-,24-,25-,26-,31-,32-,35+,36+,37-,38-,41-,42?/m1/s1

SMILES string

OC[C@H]1O[C@@H](Oc2cccc3[C@@H]([C@@H]4c5cccc(O[C@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)c5C(=O)c7c(O)cc(cc47)C(O)=O)c8cc(cc(O)c8C(=O)c23)C(O)=O)[C@H](O)[C@@H](O)[C@@H]1O

grade

analytical standard

assay

≥96.0% (HPLC)

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

food and beverages

format

neat

Quality Level

100

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General description

Sennoside A is a hydroxy anthracene glycoside generally present in the polyherbal formulations that contain Cassia angustifolia leaves, which is used in the treatment of constipation.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCK5929
BCCJ3940
BCCF3621
BCCD1720
BCBZ8154

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Status of sennosides content in various Indian herbal formulations: method standardization by HPTLC
Aktar W, et al.
Bangladesh Journal of Pharmacology, 3, 64-68 (2008)
Yen-Chun Chen et al.
Life sciences, 84(25-26), 915-922 (2009-04-28)
To address the possibility that sennoside B inhibition of cell proliferation is mediated via interference with platelet-derived growth factor (PDGF) signaling. Human osteosarcoma MG63 cells were treated with PDGF in the presence or absence of sennoside B. Activation of the
Kento Takayama et al.
Chemical & pharmaceutical bulletin, 59(9), 1106-1109 (2011-09-02)
Daiokanzoto (DKT, combination of rhubarb and glycyrrhiza), a Kampo medicine, is clinically effective for constipation. Sennoside A is well known to induce diarrhea. Sennoside A is a prodrug that is transformed into an active metabolite, rheinanthrone, by intestinal bacteria. In
Manuk N Manukyan et al.
Surgical laparoscopy, endoscopy & percutaneous techniques, 21(2), 90-93 (2011-04-08)
The aim of this study is to assess 2 different bowel-cleansing agents. The patients were prospectively randomized to 2 arms of sodium phosphate versus Sennoside A+B calcium preparation. Laboratory assessment, body weight, height, and vital signs were obtained at baseline
Philippa Helen Hawley et al.
Journal of palliative medicine, 11(4), 575-581 (2008-05-06)
Constipation is a common and distressing condition in patients with cancer, especially those taking opioid analgesics. Many institutions prevent and treat constipation with titrated laxatives, which is known as a bowel protocol. An effective and well-tolerated bowel protocol is a
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