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68909

Supelco

Sennoside A

analytical standard

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Empirical Formula (Hill Notation):
C42H38O20
CAS Number:
Molecular Weight:
862.74
Beilstein:
5723746
EC Number:
MDL number:
UNSPSC Code:
85151701
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

Assay

≥96.0% (HPLC)

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

food and beverages

format

neat

SMILES string

OC[C@H]1O[C@@H](Oc2cccc3[C@@H]([C@@H]4c5cccc(O[C@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)c5C(=O)c7c(O)cc(cc47)C(O)=O)c8cc(cc(O)c8C(=O)c23)C(O)=O)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C42H38O20/c43-11-23-31(47)35(51)37(53)41(61-23)59-21-5-1-3-15-25(17-7-13(39(55)56)9-19(45)27(17)33(49)29(15)21)26-16-4-2-6-22(60-42-38(54)36(52)32(48)24(12-44)62-42)30(16)34(50)28-18(26)8-14(40(57)58)10-20(28)46/h1-10,23-26,31-32,35-38,41-48,51-54H,11-12H2,(H,55,56)(H,57,58)/t23-,24-,25-,26-,31-,32-,35+,36+,37-,38-,41-,42?/m1/s1

InChI key

IPQVTOJGNYVQEO-GTCVFCFLSA-N

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General description

Sennoside A is a hydroxy anthracene glycoside generally present in the polyherbal formulations that contain Cassia angustifolia leaves, which is used in the treatment of constipation.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Status of sennosides content in various Indian herbal formulations: method standardization by HPTLC
Aktar W, et al.
Bangladesh Journal of Pharmacology, 3, 64-68 (2008)
Huifang Li et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(3), 302-304 (2012-05-10)
To determine the difference on purgative biopotency of different processed products of rhubarb and compare rhubarb before and after preparation. The prime biopotency of rhubarb reference substance was determined by comparing with the control substance of sennoside B using rat
Emi Matsui et al.
Biological & pharmaceutical bulletin, 34(9), 1438-1442 (2011-09-02)
Daiokanzoto (DKT), a Kampo medicine that includes the combination of two crude drugs (rhubarb and glycyrrhiza), is clinically effective for constipation. The aim of this study is to clarify the influence of glycyrrhiza, three glycyrrhiza constituents (glycyrrhizin, liquiritin, and liquiritin
Jing Xiao et al.
Wei sheng yan jiu = Journal of hygiene research, 40(3), 355-357 (2011-06-24)
To develop an analytical method for determination of sennoside A and sennoside B simultaneously in health food by high performance liquid chromatography (HPLC). Samples were extracted by ultrasound extraction and determined by HPLC with a UV detector. Using a Synergi
Mitsuko Takahashi et al.
Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan, 50(6), 297-303 (2010-01-13)
Sennoside A and B were detected in 21 commercial health tea products surveyed in 2000-2007, but there were 8 products in which the leaves could not be identified as senna because the leaves had become discolored. The results of assay

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