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Hippuric acid

analytical standard

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Synonym(s):
N-Benzoylglycine, Benzoylaminoacetic acid
Linear Formula:
C6H5CONHCH2COOH
CAS Number:
495-69-2
Molecular Weight:
179.17
Beilstein:
1073987
EC Number:
207-806-3
MDL number:
MFCD00002692
UNSPSC Code:
41116107
NACRES:
NA.24

grade

analytical standard

Assay

≥97.5% (GC)

shelf life

limited shelf life, expiry date on the label

mp

187-191 °C (lit.)

application(s)

clinical testing

format

neat

SMILES string

OC(=O)CNC(=O)c1ccccc1

InChI

1S/C9H9NO3/c11-8(12)6-10-9(13)7-4-2-1-3-5-7/h1-5H,6H2,(H,10,13)(H,11,12)

InChI key

QIAFMBKCNZACKA-UHFFFAOYSA-N

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General description

Hippuric acid, the glycine conjugate of benzoic acid, is formed via a biotransformation process. From scientific literature, it is reported to be found as an excretory product in urine. Hippuric acid is also known to be catabolically synthesized from benzene-type aromatic compounds, believed to be originated from various factors such as environmental exposures, basic human liver metabolism of protein catabolism, cyclic sugar type-compounds, quinic acid, etc.

Application

Hippuric acid may be used as an analytical reference standard for the quantification of the analyte in the following:
  • Human biological fluids using high-performance liquid chromatography (HPLC) with UV detection.
  • Human and rat urine samples using gas chromatography–mass spectrometry (GC–MS).
  • Human urine samples using GC equipped with a flame ionization detector.

Recommended products

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WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Determination of benzoic acid and hippuric acid in human plasma and urine by high-performance liquid chromatography
Kubota K, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 425, 67-75 (1988)
Simultaneous determination of urinary hippuric acid, o-, m-and p-methylhippuric acids, mandelic acid and phenylglyoxylic acid for biomonitoring of volatile organic compounds by gas chromatography-mass spectrometry.
Ohashi Y, et al.
Analytica Chimica Acta, 566(2), 167-171 (2006)
Ronald W Pero
Current clinical pharmacology, 5(1), 67-73 (2009-11-07)
Hippuric acid has been a major human metabolite for years. However, there is no well-known documented health benefit associated with it except for excretion of environmental-toxic exposures of aromatic compounds such as toluene, or from dietary protein degradation and re-synthesis
P Kongtip et al.
Journal of chromatography. B, Biomedical sciences and applications, 751(1), 199-203 (2001-03-10)
A modified method for the simultaneous determination of hippuric acid (HA) and o-, m- and p-methylhippuric acids (o-, m- and p-MHAs) in urine is described. These metabolites were extracted, derivatized into their methyl ester derivatives and analyzed using a gas

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