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Merck
CN

67268

Myricitrin

analytical standard

Synonym(s):

3,3′,4′,5,5′,7-Hexahydroxyflavone 3-O-rhamnoside, Myricetin 3-O-α-L-rhamnopyranoside, Myricetin 3-O-rhamnoside, Myricitroside

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About This Item

Empirical Formula (Hill Notation):
C21H20O12
CAS Number:
17912-87-7
Molecular Weight:
464.38
NACRES:
NA.24
PubChem Substance ID:
329760524
UNSPSC Code:
85151701
EC Number:
241-856-7
MDL number:
MFCD00016930

Key Documents

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Product Name

Myricitrin, analytical standard

InChI key

DCYOADKBABEMIQ-OWMUPTOHSA-N

InChI

1S/C21H20O12/c1-6-14(26)17(29)18(30)21(31-6)33-20-16(28)13-9(23)4-8(22)5-12(13)32-19(20)7-2-10(24)15(27)11(25)3-7/h2-6,14,17-18,21-27,29-30H,1H3/t6-,14-,17+,18+,21-/m0/s1

SMILES string

C[C@@H]1O[C@@H](OC2=C(Oc3cc(O)cc(O)c3C2=O)c4cc(O)c(O)c(O)c4)[C@H](O)[C@H](O)[C@H]1O

grade

analytical standard

assay

≥95.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

food and beverages

format

neat

storage temp.

2-8°C

Quality Level

100

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Application

Myricitrin may be used as an analytical reference standard for determination of the analyte in Folium Rhododendri Micranthi extract using high-performance liquid chromatography. It may also be used as an external standard in the validation of both commercial herbal medicines and crude material of Myrcia uniflora extracts using high-performance liquid chromatography technique.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

General description

Myricitrin is a plant compound, isolated from Folium Rhododendri Micranthi, which acts as a nitric oxide and protein kinase inhibitor and is found to exhibit antipsychotic-like effect in animal models.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN9380
BCCM8363
BCCJ3387
BCCG9111
BCCC2819

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Development and validation of a HPLC method for standardization of herbal and commercial extracts of Myrcia uniflora
Revista Brasileira de Farmacognosia, 21(3), 402-406 (2011)
Dyskinesias: New Insights for the Healthcare Professional: 2012 Edition: ScholarlyBrief, 47(8), 714-717 (2012)
Flavia Carla Meotti et al.
Free radical biology & medicine, 44(1), 109-120 (2007-10-30)
Flavonoids are increasingly being ingested by the general population as chemotherapeutic and anti-inflammatory agents. They are potentially toxic because of their conversion to free radicals and reactive quinones by peroxidases. Little detailed information is available on how flavonoids interact with
M Pereira et al.
Progress in neuro-psychopharmacology & biological psychiatry, 35(7), 1636-1644 (2011-06-22)
Myricitrin is a nitric oxide (NO) and protein kinase C (PKC) inhibitor that has central nervous system activity, including anxiolytic-like action. Nitric oxide inhibitors blocked the behavioral effects of apomorphine, suggesting an antipsychotic-like effect. Furthermore, PKC inhibition reduced psychotic symptoms
Jeffrey R Jones et al.
Journal of natural products, 74(1), 38-44 (2010-12-15)
Target-based drug discovery for Alzheimer's disease (AD) centered on modulation of the amyloid β peptide has met with limited success. Therefore, recent efforts have focused on targeting the microtubule-associated protein tau. Tau pathologically accumulates in more than 15 neurodegenerative diseases
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