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Merck
CN

64340

DL-Methionine

≥99.0% (NT)

Synonym(s):

(±)-2-Amino-4-(methylmercapto)butyric acid, DL-2-Amino-4-(methylthio)butanoic acid

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About This Item

Linear Formula:
CH3SCH2CH2CH(NH2)COOH
CAS Number:
Molecular Weight:
149.21
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
200-432-1
MDL number:
Beilstein/REAXYS Number:
636185
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Product Name

DL-Methionine, ≥99.0% (NT)

Quality Level

assay

≥99.0% (NT)

form

powder or crystals

optical activity

[α]/D, c = 5 in 5 M HCl (inactive)

concentration

5% in 5 M HCl

ign. residue

≤0.05%

color

white

mp

280 °C (dec.) (lit.)

solubility

5 M HCl: 1 g/10 mL, clear, colorless to almost colorless

suitability

corresponds for TLC

application(s)

peptide synthesis

SMILES string

CSCCC(N)C(O)=O

InChI

1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)

InChI key

FFEARJCKVFRZRR-UHFFFAOYSA-N

Application

DL-Methionine has been used to study the susceptibility of methionine to oxidation during the development of monoclonal antibodies.

Biochem/physiol Actions

Methionine is an essential amino acid which acts a precursor for transmethylation and transsulfuration. In proteins, L-methionine is the biologically active form. D-methionine is converted to L-methionine by enzymes in the body. The adenosylation of methionine results in the formation of S-adenosyl-L-methionine (SAM), which serves as a methyl donor to various substances. L-Methionine′s metabolic product glutathione is known to regulate immune response and has antiviral action.


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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Rapid assessment of oxidation via middle-down LCMS correlates with methionine side-chain solvent-accessible surface area for 121 clinical stage monoclonal antibodies
Rong Yang
MAbs (2017)
L-methionine as immune supportive supplement: a clinical evaluation.
Van Brummelen and du Toit D
Amino Acids, 33(1), 157-163 (2007)
Bio-Methionine Production from Glucose - Cost Analysis - Methionine E31A (2016)



Global Trade Item Number

SKUGTIN
T0254-1KG04061837334634
T0254-25G04061835363063
T0254-100G04061835363056
T0254-500G04061837334641
V900470-50G04061833615119
T261000004061837342592
T8941-100G04061837379871
108374010004022536103549
108374050004022536103556
108374901004022536692838
108396100004022536104003
1700501-200MG04061838750365
93659-250G04061833441428
93659-10G04061833283059
108374001004022536103532
108396901004022536732701
816017002504022536423852
816017010004022536423869
T0254-1G04061837334627
T0254-5G04061835363070
T8941-25G04061837379901