Skip to Content
Merck
CN
All Photos(1)

Documents

Safety Information

63406

Sigma-Aldrich

Methyl malonyl chloride

purum, ≥97.0% (AT)

Sign Into View Organizational & Contract Pricing
All Photos(1)
Synonym(s):
Methyl chloroformylacetate
Linear Formula:
CH3OCOCH2COCl
CAS Number:
37517-81-0
Molecular Weight:
136.53
Beilstein:
1754078
EC Number:
253-540-6
MDL number:
MFCD00013657
UNSPSC Code:
12352100
PubChem Substance ID:
329759858
NACRES:
NA.22

grade

purum

Quality Level

200

Assay

≥97.0% (AT)

refractive index

n20/D 1.432 (lit.)
n20/D 1.432

bp

57-59 °C/12 mmHg (lit.)

density

1.273 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

COC(=O)CC(Cl)=O

InChI

1S/C4H5ClO3/c1-8-4(7)2-3(5)6/h2H2,1H3

InChI key

UTBCRHAMJFMIIR-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

Application

Methyl malonyl chloride can be used in the synthesis of methyl 7-hydroxy[1,3]thiazolo[5,4-b]pyridin-5(4H)-one-6-carboxylates and 6-carboxamides, which can act like HIV integrase strand transfer inhibitors. It can also be used in the synthesis of Strychnos alkaloids like (-)-leuconicine A and (-)-leuconicine B.

Caution

may discolor to yellow on storage

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H314,H335

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 3

Flash Point(F)

closed cup

Flash Point(C)

closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

新产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

"Total synthesis of (-)-leuconicine A and B"
Sirasani G and Andrade.BR
Organic Letters, 13(17), 4736-4737 (2011)
"Synthesis and HIV-integrase strand transfer inhibition activity of 7-hydroxy [1, 3] thiazolo [5, 4-b]pyridin-5 (4H)-ones"
Boros.EE, et al.
Bioorganic & Medicinal Chemistry, 16(21), 5668-5672 (2006)
Elif Okutan et al.
Journal of fluorescence, 26(6), 2333-2343 (2016-11-01)
Colorimetric fluorescent chemosensors 4 and 5 based on mono- and di- styryl borondipyrromethenes (BODIPY) linked methyl malonyl were designed for detection of hemoglobin (HgB). Their sensing behavior toward various analytes (Br

Protocols

Analytical Method: Copper (total) in feedstuffs

Photometric determination with Cuprizon subsequent to acid mineralisation

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service