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61347

Supelco

10,11-Dihydro-10-hydroxycarbamazepine

analytical standard

Synonym(s):

10,11-Dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide, Licarbazepine

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About This Item

Empirical Formula (Hill Notation):
C15H14N2O2
CAS Number:
29331-92-8
Molecular Weight:
254.28
Beilstein:
1540211
MDL number:
MFCD00871817
UNSPSC Code:
41116107
PubChem Substance ID:
329759441
NACRES:
NA.24

grade

analytical standard

Quality Level

100

Assay

≥99% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C15H14N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8,14,18H,9H2,(H2,16,19)

InChI key

BMPDWHIDQYTSHX-UHFFFAOYSA-N

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General description

10,11-Dihydro-10-hydroxycarbamazepine is a 10-hydroxy derivative and an active metabolite of oxcarbazepine.
10,11-Dihydro-10-hydroxycarbamazepine is an active metabolite of the antiepileptic drug, oxcarbazepine.

Application

10,11-Dihydro-10-hydroxycarbamazepine may be used as a reference standard in the determination of 10,11-dihydro-10-hydroxycarbamazepine in biological samples using liquid chromatography, liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) and high performance liquid chromatography coupled with ultraviolet detector (HPLC-UV).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Environment
GHS09

Hazard Statements

H411

Precautionary Statements

P273

Hazard Classifications

Aquatic Chronic 2

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

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Liquid chromatographic analysis of oxcarbazepine and its metabolites in plasma and saliva after a novel microextraction by packed sorbent procedure.
Saracino M A, et al.
Analytica Chimica Acta, 661(2), 222-228 (2010)
Anne-Catherine Servais et al.
Journal of chromatography. A, 1467, 306-311 (2016-07-22)
A LC method using a chiral stationary phase (CSP) with cellulose tris(3-chloro-4-methylphenylcarbamate) as chiral selector in polar organic mode (POM) was developed for the separation of the biopharmaceutic classification system (BCS) class II chiral prodrug eslicarbazepine acetate (ESL) and its
Simultaneous quantitative analysis of oxcarbazepine and 10, 11-dihydro-10-hydroxycarbamazepine in human plasma by liquid chromatography-electrospray tandem mass spectrometry.
Maia SdBM, et al.
Journal of Pharmaceutical and Biomedical Analysis, 45(2), 304-311 (2007)
Johannes Pohl et al.
Environmental science & technology, 54(5), 2913-2921 (2020-01-29)
Carbamazepine (CBZ) is an anticonvulsant medication with highly persistent properties in the aquatic environment, where it has the potential to affect nontarget biota. Because CBZ and many other pharmaceuticals are not readily removed in conventional sewage treatment plants (STP), additional
First dose and steady-state pharmacokinetics of oxcarbazepine and its 10-hydroxy metabolite.
Dickinson R G, et al.
European Journal of Clinical Pharmacology, 37(1), 69-74 (1989)
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