61347
10,11-Dihydro-10-hydroxycarbamazepine
analytical standard
Synonym(s):
10,11-Dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide, Licarbazepine
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About This Item
Empirical Formula (Hill Notation):
C15H14N2O2
CAS Number:
Molecular Weight:
254.28
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
Beilstein/REAXYS Number:
1540211
MDL number:
SMILES string
N1(c2c(cccc2)C(Cc3c1cccc3)O)C(=O)N
InChI key
BMPDWHIDQYTSHX-UHFFFAOYSA-N
InChI
1S/C15H14N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8,14,18H,9H2,(H2,16,19)
grade
analytical standard
assay
≥99% (HPLC)
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
Quality Level
General description
10,11-Dihydro-10-hydroxycarbamazepine is an active metabolite of the antiepileptic drug, oxcarbazepine.
10,11-Dihydro-10-hydroxycarbamazepine is a 10-hydroxy derivative and an active metabolite of oxcarbazepine.
Application
10,11-Dihydro-10-hydroxycarbamazepine may be used as a reference standard in the determination of 10,11-dihydro-10-hydroxycarbamazepine in biological samples using liquid chromatography, liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) and high performance liquid chromatography coupled with ultraviolet detector (HPLC-UV).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
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Johannes Pohl et al.
Environmental science & technology, 54(5), 2913-2921 (2020-01-29)
Carbamazepine (CBZ) is an anticonvulsant medication with highly persistent properties in the aquatic environment, where it has the potential to affect nontarget biota. Because CBZ and many other pharmaceuticals are not readily removed in conventional sewage treatment plants (STP), additional
Anne-Catherine Servais et al.
Journal of chromatography. A, 1467, 306-311 (2016-07-22)
A LC method using a chiral stationary phase (CSP) with cellulose tris(3-chloro-4-methylphenylcarbamate) as chiral selector in polar organic mode (POM) was developed for the separation of the biopharmaceutic classification system (BCS) class II chiral prodrug eslicarbazepine acetate (ESL) and its
Simultaneous quantitative analysis of oxcarbazepine and 10, 11-dihydro-10-hydroxycarbamazepine in human plasma by liquid chromatography-electrospray tandem mass spectrometry.
Maia SdBM, et al.
Journal of Pharmaceutical and Biomedical Analysis, 45(2), 304-311 (2007)
Liquid chromatographic analysis of oxcarbazepine and its metabolites in plasma and saliva after a novel microextraction by packed sorbent procedure.
Saracino M A, et al.
Analytica Chimica Acta, 661(2), 222-228 (2010)
Simultaneous high-performance liquid chromatography determination of carbamazepine and five of its metabolites in plasma of epileptic patients.
Mandrioli R, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 762(2), 109-116 (2001)
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