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61234

Supelco

α-Ketoglutaric acid

analytical standard

Synonym(s):

2-Oxoglutaric acid, 2-Oxopentanedioic acid

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About This Item

Linear Formula:
HOOCCH2CH2COCOOH
CAS Number:
328-50-7
Molecular Weight:
146.10
Beilstein:
1705689
EC Number:
206-330-3
MDL number:
MFCD00004165
UNSPSC Code:
41116107
NACRES:
NA.24
To inquire about this product 61234, please contact your local Merck office or dealer. Contact Technical Service

grade

analytical standard

Assay

99.0-101.0% (T)

shelf life

limited shelf life, expiry date on the label

application(s)

clinical testing

format

neat

storage temp.

2-8°C

SMILES string

OC(=O)CCC(=O)C(O)=O

InChI

1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)

InChI key

KPGXRSRHYNQIFN-UHFFFAOYSA-N

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Show Differences

1 of 4

This Item
543758110856796
Micro particles based on silicon dioxide size: 5 μm

44054

Micro particles based on silicon dioxide

Micro particles based on silicon dioxide size: 4 μm

54375

Micro particles based on silicon dioxide

Micro particles based on silicon dioxide size: 2 μm

81108

Micro particles based on silicon dioxide

Micro particles based on silicon dioxide size: 0.5 μm

56796

Micro particles based on silicon dioxide

particle size

5 μm std dev ≤0.35 μm

particle size

4 μm std dev ≤0.3 μm

particle size

2 μm std dev ≤0.2 μm

particle size

0.5 μm

grade

analytical standard

grade

analytical standard

grade

analytical standard

grade

analytical standard

application(s)

glass & ceramic
industrial qc
pharmaceutical

application(s)

glass & ceramic
industrial qc
pharmaceutical

application(s)

glass & ceramic
industrial qc
pharmaceutical

application(s)

glass & ceramic
industrial qc
pharmaceutical

form

aqueous suspension

form

aqueous suspension

form

aqueous suspension

form

aqueous suspension

concentration

5% (solids)

concentration

5% (solids)

concentration

5% (solids)

concentration

5% (solids)

General description

α-Ketoglutaric acid, an α-ketoacid, is identified as a potential, renal cell carcinoma (RCC) biomarker via urinary metabolomic profiling.[1] It plays an important role in living beings as an angiogenesis suppressor.[2]

Application

α-Ketoglutaric acid may be used as an analytical reference standard for the quantification of the analyte in the following:
  • Human plasma samples using gas-chromatography coupled to mass spectrometry.[2]
  • Beer samples using high-performance liquid chromatography with UV detection, and further confirmed by high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS).[3]
  • Fruits and vegetables using HPLC-MS/MS.[4]

Pictograms

Corrosion
GHS05

Signal Word

Danger

Hazard Statements

H318

Precautionary Statements

P280 - P305 + P351 + P338 + P310

Hazard Classifications

Eye Dam. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    Certificates of Analysis (COA)

    Lot/Batch Number
    BCCM4540
    BCCJ0763
    BCCD4395
    BCCC4626
    BCBZ4747

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    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

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    Single determination of ?-ketoglutaric acid and pyruvic acid in beer by HPLC with UV detection
    Montenegro P, et al.
    Analytical Methods : Advancing Methods and Applications, 3(5), 1207-1212 (2011)
    Simultaneous quantitative determination of ?-ketoglutaric acid and 5-hydroxymethylfurfural in human plasma by gas chromatography?mass spectrometry
    Wagner MB, et al.
    Analytical and Bioanalytical Chemistry, 396(7), 2629-2637 (2010)
    Determination of organic acids in fruits and vegetables by liquid chromatography with tandem-mass spectrometry
    Flores P, et al.
    Food Chemistry, 132(2), 1049-1054 (2012)
    Simultaneous determination of urinary quinolinate, gentisate, 4-hydroxybenzoate, and ?-ketoglutarate by high-performance liquid chromatography-tandem mass spectrometry
    Chen S, et al.
    Analytical Methods : Advancing Methods and Applications, 7(16), 6572-6578 (2015)
    Gas chromatographic profiling and pattern recognition analysis of urinary organic acids from uterine myoma patients and cervical cancer patients
    Kim R-K, et al.
    Journal of Chromatography. B, Biomedical Sciences and Applications, 712(1-2), 11-22 (1998)

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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