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58168

Sigma-Aldrich

Ionomycin calcium salt from Streptomyces conglobatus

≥80% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C41H70CaO9
CAS Number:
56092-82-1
Molecular Weight:
747.07
Beilstein:
1416163
MDL number:
MFCD00083634
UNSPSC Code:
12352200
PubChem Substance ID:
329758403

Assay

≥80% (HPLC)

antibiotic activity spectrum

Gram-positive bacteria

Mode of action

cell membrane | interferes

storage temp.

−20°C

SMILES string

C[C@@H]1CCC(=O)O[Ca]OC(=CC(=O)[C@@H](C)C[C@@H](C)C1)[C@H](C)C[C@H](C)C\C=C\[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]2CC[C@](C)(O2)[C@H]3CC[C@](C)(O3)[C@@H](C)O

InChI

1S/C41H72O9.Ca/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42;/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47);/q;+2/p-2/b13-11+,34-24-;/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+;/m1./s1

InChI key

WKRWUYKLUMMAKG-WYGBAUISSA-L

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Biochem/physiol Actions

Ca2+ ionophore that is more effective than A23187 as a mobile ion carrier for Ca2+.
Ca2+ ionophore that is more effective than A23187 as a mobile ion carrier for Ca2+; non-fluorescent; used to study Ca2+ transport across biological membranes; induces apoptotic degeneration of embryonic cortical neurons.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Nonfluorescent ionophoric antibiotic which exhibits a greater selectivity for Ca2+ over Mg2+ than does A23187

replaced by

Product No.
Description
Pricing

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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C B Wollheim et al.
The Journal of biological chemistry, 259(4), 2262-2267 (1984-02-25)
Changes in the concentration of free cytosolic Ca2+ [( Ca2+]i), membrane potential, and immunoreactive insulin release were measured in suspensions of RINm5F cells. [Ca2+]i was monitored with the intracellularly trapped fluorescent Ca2+ indicator quin 2. Changes in membrane potential were
R Gennaro et al.
Proceedings of the National Academy of Sciences of the United States of America, 81(5), 1416-1420 (1984-03-01)
The cytosolic concentration of free Ca2+ in bovine neutrophils was monitored by using the intracellular Ca2+ indicator quin2, 2-[[2-bis(acetylamino)-5-methylphenoxy]methyl-6-methoxy-8- bis(acetylamino)]quinoline. Neutrophils at rest have a cytosolic Ca2+ concentration of 85 +/- 5 nM, which in 2-4 min increases to 300-400
C Liu et al.
The Journal of biological chemistry, 253(17), 5892-5894 (1978-09-10)
The ionophorous properties of a new antibiotic, ionomycin, have been studied. It was found that the antibiotic is capable of extracting calcium ion from the bulk of an aqueous phase into an organic phase. The antibiotic also acts as a
Konstantin V Salojin et al.
PloS one, 9(5), e98151-e98151 (2014-05-24)
Mammalian sterile 20-like kinase 1 (Mst1) is a MAPK kinase kinase kinase which is involved in a wide range of cellular responses, including apoptosis, lymphocyte adhesion and trafficking. The contribution of Mst1 to Ag-specific immune responses and autoimmunity has not
Katrien Pletinckx et al.
European journal of immunology, 45(2), 480-491 (2014-11-11)
Anergic T cells can survive for long time periods passively in a hyporesponsive state without obvious active functions. Thus, the immunological reason for their maintenance is unclear. Here, we induced peptide-specific anergy in T cells from mice by coculturing these cells with
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