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574724

Sigma-Aldrich

Acetonitrile solution

suitable for HPLC, contains 0.05 % (v/v) trifluoroacetic acid

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Synonym(s):
ACN, Cyanomethane, Ethyl nitrile, Methyl cyanide
Linear Formula:
CH3CN
CAS Number:
75-05-8
Molecular Weight:
41.05
Beilstein:
4124158
EC Number:
200-835-2
MDL number:
MFCD00001878
UNSPSC Code:
12190000
PubChem Substance ID:
57651625
NACRES:
NA.03

vapor density

1.41 (vs air)

Quality Level

100

vapor pressure

72.8 mmHg

form

liquid

contains

0.05 % (v/v) trifluoroacetic acid

expl. lim.

8 % (lit.)

technique(s)

HPLC: suitable

bp

81-82 °C (lit.)

mp

-48 °C (lit.)

density

0.782 g/mL at 25 °C

format

mixture

SMILES string

CC#N

InChI

1S/C2H3N/c1-2-3/h1H3

InChI key

WEVYAHXRMPXWCK-UHFFFAOYSA-N

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General description

The product is an acetonitrile solution containing 0.05%v/v trifluoroacetic acid. This pre-blended mobile phase solvent is of high purity that reduces time-consuming preparation and prevents instrument downtime because of impure mobile phases. Trifluoroacetic acid/acetonitrile mobile phase system is generally employed for peptide separation. Acetonitrile (MeCN), an organic solvent has low viscosity, high elution strength and is UV transparent at low wavelength. Trifluoroacetic acid (TFA) is commonly used as a mobile phase additive. It is a UV transparent, volatile acid that forms hydrophobic negatively charged trifluoroacetate ion.

Preparation Note

Product filtered through a 0.2 μm filter

Pictograms

FlameExclamation mark
GHS02,GHS07

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

WGK

WGK 2

Flash Point(F)

closed cup

Flash Point(C)

closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

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Optimum concentration of trifluoroacetic acid for reversed-phase liquid chromatography of peptides revisited.
Chen Y, et al.
Journal of Chromatography A, 1043(1), 9-18 (2004)
Eagleson M.
Concise Encyclopedia Chemistry, 6-6 (1994)
Acetonitrile, the polarity chameleon.
Zarzycki PK, et al.
Analytical and Bioanalytical Chemistry, 397(3), 905-908 (2010)
Maria de la Paz Celorio-Mancera et al.
Insect biochemistry and molecular biology, 61, 34-45 (2015-05-03)
More than half of the proteome from mandibular glands in caterpillars is represented by chemosensory proteins. Based on sequence similarity, these proteins are putative transporters of ligands to gustatory receptors in sensory organs of insects. We sought to determine whether
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The neuropathological substrate of dementia in patients with Parkinson's disease is still under debate, particularly in patients with insufficient alternate neuropathology for other degenerative dementias. In patients with pure Lewy body Parkinson's disease, previous post-mortem studies have shown that dopaminergic
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