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Merck
CN

56601

Icariin

analytical standard

Synonym(s):

4′-O-methyl-8-γ,γ-dimethylallylkaempferol-3-rhamnoside-7-glucoside

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About This Item

Empirical Formula (Hill Notation):
C33H40O15
CAS Number:
489-32-7
Molecular Weight:
676.66
NACRES:
NA.24
PubChem Substance ID:
329758223
UNSPSC Code:
85151701
MDL number:
MFCD00210516

Key Documents

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Product Name

Icariin, analytical standard

InChI key

TZJALUIVHRYQQB-XLRXWWTNSA-N

SMILES string

COc1ccc(cc1)C2=C(O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)C(=O)c4c(O)cc(O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)c(C\C=C(\C)C)c4O2

InChI

1S/C33H40O15/c1-13(2)5-10-17-19(45-33-28(42)26(40)23(37)20(12-34)46-33)11-18(35)21-24(38)31(48-32-27(41)25(39)22(36)14(3)44-32)29(47-30(17)21)15-6-8-16(43-4)9-7-15/h5-9,11,14,20,22-23,25-28,32-37,39-42H,10,12H2,1-4H3/t14-,20+,22-,23+,25+,26-,27+,28+,32-,33+/m0/s1

grade

analytical standard

assay

≥95% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

format

neat

storage temp.

2-8°C

Quality Level

100

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Application

Icariin has been used as a test material to investigate its, in vitro effect in promoting mouse hair follicle growth, which is assessed by vibrissae hair follicle (VHF) organ-culture model.
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Biochem/physiol Actions

Flavonoid glucoside derived from the the Epimedium plant genus. This pharmacologically active constituent or its derivatives have been shown to enhance bone formation, modulate multidrug resistance, enhance neuronal viability, stimulate angiogenesis, and exhibit antioxidant activity.

General description

Icariin is a major flavonoid isolated from Epimedium spp. leaves, used as a traditional Chinese medicine to nourish the kidney and reinforce yang.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN4055
BCCL3020
BCCL3021
BCCH9073
BCCG6229

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Icariin promotes mouse hair follicle growth by increasing insulin?like growth factor 1 expression in dermal papillary cells.
Su SY, et al.
Clinical and Experimental Dermatology, 42(3), 287-294 (2017)
Transforming Growth Factors?Advances in Research and Application (2012)

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