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55591

Supelco

Oxymetazoline hydrochloride

analytical standard

Synonym(s):

2-(3-Hydroxy-2,6-dimethyl-4-t-butylbenzyl)-2-imidazoline hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C16H24N2O · HCl
CAS Number:
2315-02-8
Molecular Weight:
296.84
EC Number:
219-015-0
MDL number:
MFCD00058147
UNSPSC Code:
41116107
PubChem Substance ID:
329758138

grade

analytical standard

Quality Level

100

Assay

≥99.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

impurities

≤0.5% water

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

Cl.Cc1cc(c(O)c(C)c1CC2=NCCN2)C(C)(C)C

InChI

1S/C16H24N2O.ClH/c1-10-8-13(16(3,4)5)15(19)11(2)12(10)9-14-17-6-7-18-14;/h8,19H,6-7,9H2,1-5H3,(H,17,18);1H

InChI key

BEEDODBODQVSIM-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

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Application

Oxymetazoline hydrochloride may be used as a reference standard in the determination of oxymetazoline hydrochloride in nasal spray formulations using high performance liquid chromatography (HPLC).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Oxymetazoline hydrochloride is a partial α2A-adrenoceptor agonist; agonist at 5-HT1A, 5-HT1B, and 5-HT1D serotonin receptors. It is a mixed agonist-antagonist at 5-HT1C serotonin receptors.

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Pictograms

Skull and crossbonesCorrosion
GHS06,GHS05

Signal Word

Danger

Hazard Statements

H300 + H330,H318,H412

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Aquatic Chronic 3 - Eye Dam. 1

Storage Class Code

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Regulatory Information

监管及禁止进口产品

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG4661
BCCB4685
BCBS5468V

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Simultaneous determination of triamcinolone acetonide and oxymetazoline hydrochloride in nasal spray formulations by HPLC.
Sudsakorn S, et al.
Journal of Pharmaceutical and Biomedical Analysis, 40(5), 1273-1280 (2006)
Sylwia K Paszun et al.
Acta poloniae pharmaceutica, 70(6), 1079-1085 (2014-01-05)
The presented study aimed at the evaluation of hydrochlorothiazide influence on cilazapril stability in model mixture and fixed dose tablet formulation. The degradation of cilazapril in the presence of hydrochlorothiazide took place according to autocatalytic reaction kinetic mechanism, described mathematically

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