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Silychristin

analytical standard

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Synonym(s):
Silymarin II
Empirical Formula (Hill Notation):
C25H22O10
CAS Number:
33889-69-9
Molecular Weight:
482.44
EC Number:
251-720-9
MDL number:
MFCD00883715
UNSPSC Code:
85151701
PubChem Substance ID:
329757729
NACRES:
NA.24

grade

analytical standard

Quality Level

100

Assay

≥90.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

impurities

≤10.0% water

application(s)

food and beverages

format

neat

storage temp.

2-8°C

SMILES string

COc1cc(ccc1O)[C@@H]2Oc3c(O)cc(cc3[C@H]2CO)[C@H]4Oc5cc(O)cc(O)c5C(=O)[C@@H]4O

InChI

1S/C25H22O10/c1-33-18-6-10(2-3-15(18)28)23-14(9-26)13-4-11(5-17(30)25(13)35-23)24-22(32)21(31)20-16(29)7-12(27)8-19(20)34-24/h2-8,14,22-24,26-30,32H,9H2,1H3/t14-,22+,23+,24-/m1/s1

InChI key

BMLIIPOXVWESJG-LMBCONBSSA-N

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General description

Silychristin is one of the congeners of flavonolignan silybin. It is usually derived from silymarin, which is extracted from the fruits of Silybum marianum (L.) Gaertn, and Asteraceae (Carduus marianus L.; milk thistle).

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Silychristin may be used as an analytical reference standard for the determination of silychristin in:
  • Herbal extracts, fruit extracts, and seed extracts of Silybum marianum by ultra-high performance liquid chromatography with diode array detection (UHPLC-DAD) and methanol extraction coupled to HPLC equipped with ultraviolet array detection (UVAD).
  • Milk thistle seeds by HPLC-UV.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Optimization and single-laboratory validation of a method for the determination of flavonolignans in milk thistle seeds by high-performance liquid chromatography with ultraviolet detection.
Mudge E, et al.
Analytical and Bioanalytical Chemistry, 407(25), 7657-7666 (2015)
Jose F Barreto et al.
Applied biochemistry and biotechnology, 105 -108, 881-889 (2003-05-02)
Milk thistle contains compounds that display hepatoxic protection properties. We examined the batch extraction of silymarin compounds from milk thistle seed meal in 50, 70, 85, and 100 degrees C water as a function of time. After 210 min of
Pharmacokinetics of pure silybin diastereoisomers and identification of their metabolites in rat plasma.
Marhol P, et al.
Journal of functional foods, 14, 570-580 (2015)
Phytochemical analysis, molecular docking and antiamnesic effects of methanolic extract of Silybum marianum (L.) Gaertn seeds in scopolamine induced memory impairment in mice.
Nazir N, et al.
Journal of Ethnopharmacology, 210(7), 198-208 (2018)
Wendy A Smith et al.
Planta medica, 71(9), 877-880 (2005-10-06)
A new natural product has been isolated from silymarin, the hepatoprotective extract of milk thistle (Silybum marianum) fruits. This was shown by NMR spectroscopy to be silychristin B (8), a diastereoisomer of the known silychristin (7). Levels of these and
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