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4-Butylresorcinol

analytical standard

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Synonym(s):
4-Butyl-1,3-benzenediol
Empirical Formula (Hill Notation):
C10H14O2
CAS Number:
18979-61-8
Molecular Weight:
166.22
Beilstein:
1942645
MDL number:
MFCD01684800
UNSPSC Code:
85151701
PubChem Substance ID:
329757528
NACRES:
NA.24

grade

analytical standard

Quality Level

100

Assay

≥97.0% (GC)

shelf life

limited shelf life, expiry date on the label

application(s)

cleaning products
cosmetics
food and beverages
personal care

format

neat

SMILES string

OC1=C(CCCC)C=CC(O)=C1

InChI

1S/C10H14O2/c1-2-3-4-8-5-6-9(11)7-10(8)12/h5-7,11-12H,2-4H2,1H3

InChI key

CSHZYWUPJWVTMQ-UHFFFAOYSA-N

Related Categories

General description

4-n-butylresorcinol is a derivative of resorcinol and a potent human tyrosinase inhibitor. It may be used to decrease skin irritation and is also known to inhibit melanin production.

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Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Statements

H302,H315,H319,H400

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2

WGK

WGK 2

Flash Point(F)

293.0 °F

Flash Point(C)

145 °C

Certificates of Analysis (COA)

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William Wargniez et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1060, 416-423 (2017-07-05)
In the present study, three laboratories independently compared percutaneous absorption and distribution of 4-n-butylresorcinol, using human skin from five donors. Each laboratory used the same protocol for percutaneous absorption studies but different LC-MS/MS analytical methods to quantify the test compound.
The efficacy and safety of 4-n-butylresorcinol 0.1% cream for the treatment of melasma: a randomized controlled split-face trial.
Huh SY, et al.
Annals of Dermatology, 22(1), 21-25 (2010)
S-J Lee et al.
International journal of cosmetic science, 39(3), 248-255 (2016-10-27)
4-n-butylresorcinol is a competitive inhibitor of tyrosinase and has been used as an antimelanogenic agent. However, its inhibition mechanism in intact cells is not fully understood. To elucidate the cellular mechanism, we compared in vitro and in vivo inhibitory effects
Justyna Odrobińska et al.
Polymers, 12(2) (2020-02-09)
A novel initiator, bromoester modified 4-n-butylresorcinol (4nBREBr2), was prepared and utilized in controlled atom transfer radical polymerization (ATRP) to obtain three series of amphiphilic copolymers. The V-shaped copolymers of methyl methacrylate (MMA), 2-hydroxyethyl methacrylate (HEMA), and poly(ethylene glycol) methyl ether
Justyna Odrobińska et al.
Materials (Basel, Switzerland), 13(16) (2020-08-09)
The amphiphilic copolymers of poly(ethylene glycol) methyl ether methacrylate (MPEGMA) and alkyne functionalized 2-hydroxyethyl methacrylate (AlHEMA) were synthesized by controlled atom transfer radical polymerization (ATRP). The reactions were carried out using the standard ATRP initiator ethyl α-bromoisobutyrate, (EiBBr) and the

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