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Neotame

analytical standard

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Synonym(s):
N-[N-(3,3-Dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester
Empirical Formula (Hill Notation):
C20H30N2O5
CAS Number:
165450-17-9
Molecular Weight:
378.46
Beilstein:
8352678
MDL number:
MFCD09039056
UNSPSC Code:
85151701
PubChem Substance ID:
329757524
E Number:
E961
NACRES:
NA.24

grade

analytical standard

Quality Level

100

Assay

≥98.0% (HPLC)

optical activity

[α]/D -41.0±3.0°, c = 0.5 in H2O

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

cleaning products
cosmetics
food and beverages
personal care

format

neat

SMILES string

COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NCCC(C)(C)C

InChI

1S/C20H30N2O5/c1-20(2,3)10-11-21-15(13-17(23)24)18(25)22-16(19(26)27-4)12-14-8-6-5-7-9-14/h5-9,15-16,21H,10-13H2,1-4H3,(H,22,25)(H,23,24)/t15-,16-/m0/s1

InChI key

HLIAVLHNDJUHFG-HOTGVXAUSA-N

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General description

Neotame is a white colored, dipeptide methyl ester, which is found to be a highly potent and non-nutritive sweetener or flavour enhancer and hence finds applications in variety of foods. It is manufactured from aspartame and 3,3-dimethylbutyraldehyde in a one-step chemical synthesis process.
Neotame is chemically related to aspartame, an artificial sweetener, used in the production of sugar-free low-calorie foodstuffs. It is approved as a food additive depending upon the food or beverage application.

Application

Neotame may be used as an analytical reference standard for the quantification of the analyte in the following:
  • Wine samples using reversed-phase high-performance liquid chromatography (RP-HPLC).
  • Wastewaters using hydrophilic interaction liquid chromatography (HILIC).
  • Food samples using high-performance liquid chromatography (HPLC).

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Joint RAO/WHO Expert Committee on Food Additives, World Health Organization
Evaluation of Certain Food Additives: Seventy-first Report of the Joint FAO/WHO Expert Committee on Food Additives (2004)
Modifying the temporal profile of the high-potency sweetener neotame
Prakash I, et al.
Journal of Agricultural and Food Chemistry, 49, 786-789 (2001)
Neotame: discovery, properties, utility
Nofre C and Tinti M-J
Food Chemistry, 69, 245-257 (2000)
Neotame as a sweetener and flavour enhancer?Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
European Food Safety Authority (EFSA)
EFSA Journal, 5(11), 581-581 (2007)
Determination of nine high-intensity sweeteners in various foods by high-performance liquid chromatography with mass spectrometric detection
Zygler A, et al.
Analytical and Bioanalytical Chemistry, 400(07), 2159-2172 (2011)
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