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Carnosol

analytical standard

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Synonym(s):
Picrosalvin
Empirical Formula (Hill Notation):
C20H26O4
CAS Number:
5957-80-2
Molecular Weight:
330.42
MDL number:
MFCD02752467
UNSPSC Code:
85151701
PubChem Substance ID:
329757507
NACRES:
NA.24

biological source

Rosemarinus officinalis L. leaves

Quality Level

100

grade

analytical standard

Assay

≥98.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

food and beverages

format

neat

storage temp.

−20°C

SMILES string

CC(C)c1cc2[C@@H]3C[C@H]4C(C)(C)CCC[C@]4(C(=O)O3)c2c(O)c1O

InChI

1S/C20H26O4/c1-10(2)11-8-12-13-9-14-19(3,4)6-5-7-20(14,18(23)24-13)15(12)17(22)16(11)21/h8,10,13-14,21-22H,5-7,9H2,1-4H3/t13-,14-,20+/m0/s1

InChI key

XUSYGBPHQBWGAD-PJSUUKDQSA-N

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General description

Carnosol is a naturally occurring phyto polyphenolor phenolic diterpene, found in rosemary, which can show a broad spectrum of applications as a an antioxidant, anticancer agent and anti-inflammatory agent.
Carnosol is one of the phenolic antioxidants present in extracts of the herb rosemary (Rosmarinus officinalis). Carnosol inhibits the formation of tumors derived using irritants such as TPA and DMBA in murine models of carcinogenesis.The effective dose reported is 1-10 μM topically or 6 μg/ml when added to supernatants of cultured cells.Addition of rosemary extracts to the diet as a 1% supplement by weight was also found to decrease the frequency of DMBA-DNA adducts.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

A phenolic diterpene with antioxidant and anticarcinogenic activities.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H317

Precautionary Statements

P280 - P302 + P352

Hazard Classifications

Skin Sens. 1

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Carnosol: a promising anti-cancer and anti-inflammatory agent
Johnson.JJ
Cancer Letters, 305, 1-7 (2011)
Ai-Hsiang Lo et al.
Carcinogenesis, 23(6), 983-991 (2002-06-26)
Carnosol is a naturally occurring phytopolyphenol found in rosemary. Carnosol functions as antioxidant and anticarcinogen. In the present study, we compared the antioxidant activity of carnosol and other compounds extracted from rosemary. Carnosol showed potent antioxidative activity in alpha,alpha-diphenyl-beta-picrylhydrazyl (DPPH)
Pi-wen Zhao et al.
Biological & pharmaceutical bulletin, 35(11), 1947-1955 (2012-09-14)
Antioxidant action is critical for maintaining the normal cardiovascular function and vascular endothelial cell is an important target of estrogen action through estrogen receptor (ER) pathway. This study is carried out to explore the antioxidant effect of carnosol in bovine
Shiu-Chen Huang et al.
Biochemical pharmacology, 69(2), 221-232 (2005-01-04)
Carnosol, a constant constituent of Rosmarinus officinalis extracts, is a phenolic diterpene shown to have antioxidant and anticarcinogen properties. In our studies, carnosol inhibited the invasion of highly metastatic mouse melanoma B16/F10 cells in vitro. First, the antimetastatic potentials of
Chien-chung Chen et al.
Acta pharmacologica Sinica, 32(1), 62-69 (2010-12-15)
To explore whether glutathione (GSH) increased through Nrf-2 activation is involved in the cytoprotective effects of carnosol in HepG2 cells. Human hepatoma cell line HepG2 were exposed to rosemarry essential oil or carnosol. Cell viability was measured using an Alamar
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