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46908

Supelco

Sulfisomidin

VETRANAL®, analytical standard

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Synonym(s):
4-Amino-N-(2,6-dimethyl-4-pyrimidinyl)benzenesulfonamide, N1-(2,6-Dimethylpyrimidin-4-yl)sulfanilamide
Empirical Formula (Hill Notation):
C12H14N4O2S
CAS Number:
515-64-0
Molecular Weight:
278.33
Beilstein:
261305
EC Number:
208-204-3
MDL number:
MFCD00010567
UNSPSC Code:
41116107
PubChem Substance ID:
329757260
NACRES:
NA.24

grade

analytical standard

Quality Level

200

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

242-243 °C (lit.)

application(s)

clinical testing

format

neat

SMILES string

Cc1cc(NS(=O)(=O)c2ccc(N)cc2)nc(C)n1

InChI

1S/C12H14N4O2S/c1-8-7-12(15-9(2)14-8)16-19(17,18)11-5-3-10(13)4-6-11/h3-7H,13H2,1-2H3,(H,14,15,16)

InChI key

YZMCKZRAOLZXAZ-UHFFFAOYSA-N

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General description

Chemical structure: sulfonamide

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

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Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 2

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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T B Vree et al.
Pharmaceutisch weekblad. Scientific edition, 6(4), 150-156 (1984-08-24)
Sulfisomidine, sulfamethomidine, sulfadimethoxine and their corresponding N4-acetyl derivatives were administered to man. The percentages of acetylation and deacetylation and those of protein binding, the half-lives of elimination and the apparent and true renal clearance values were measured. No acetylation phenotype
Lack of oxidative pathways in the metabolism of sulphisomidine by the turtle Pseudemys scripta elegans.
T B Vree et al.
Journal of veterinary pharmacology and therapeutics, 12(4), 459-462 (1989-12-01)
S P Boom et al.
The Journal of pharmacy and pharmacology, 45(7), 614-617 (1993-07-01)
To investigate whether dogs are able to excrete acetylated drugs by active transport, the plasma kinetics and renal excretion of the N4-acetyl metabolites of sulphasomidine and sulphadimethoxine were studied in the beagle dog after a rapid intravenous bolus injection. Two
H Van Gogh et al.
Research in veterinary science, 48(2), 152-157 (1990-03-01)
The influence of gestation on the pharmacokinetics of four sulphonamides was studied in goats before, during and after pregnancy. Similar doses were given as intravenous boluses of 50 mg kg-1 each. Results were compared with those of non-pregnant goats to
K Melby et al.
Acta pathologica, microbiologica, et immunologica Scandinavica. Section B, Microbiology, 91(6), 383-387 (1983-12-01)
One hundred and nine strains of Haemophilus influenzae recovered from clinical specimens were examined for antibiotic sensitivity pattern and capsular types. All strains from blood cultures, cerebrospinal fluid and a joint aspirate were type b whereas most of the isolates
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