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Merck
CN

46494

Nifuroxazide

VETRANAL®, analytical standard

Synonym(s):

5-Nitro-2-furaldehyde p-hydroxybenzoylhydrazone

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About This Item

Empirical Formula (Hill Notation):
C12H9N3O5
CAS Number:
965-52-6
Molecular Weight:
275.22
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329757202
EC Number:
213-522-0
Beilstein/REAXYS Number:
4264976
MDL number:
MFCD00079482

Key Documents

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InChI key

YCWSUKQGVSGXJO-NTUHNPAUSA-N

InChI

1S/C12H9N3O5/c16-9-3-1-8(2-4-9)12(17)14-13-7-10-5-6-11(20-10)15(18)19/h1-7,16H,(H,14,17)/b13-7+

SMILES string

Oc1ccc(cc1)C(=O)N\N=C\c2ccc(o2)[N+]([O-])=O

grade

analytical standard

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

clinical testing

format

neat

Quality Level

200

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General description

Nifuroxazide is an oral antibiotic, which may be used for the treatment of diarrhea.

Application

Nifuroxazide may be used as a reference standard in the determination of the analyte in plasma samples using high-performance liquid chromatography (HPLC).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCK3952
BCCF2302
BCBW4413
BCBW1543

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Mariane B Fernandes et al.
Toxicology in vitro : an international journal published in association with BIBRA, 26(3), 535-540 (2012-01-31)
It is important to determine the toxicity of compounds and co-solvents that are used in cell monolayer permeability studies to increase confidence in the results obtained from these in vitro experiments. This study was designed to evaluate the cytotoxicity of
JAK-STAT Pathway in Disease (2009)
Fávero Reisdorfer Paula et al.
Bioorganic & medicinal chemistry, 17(7), 2673-2679 (2009-03-24)
In this study, in vitro anti-T. cruzi activity assays of nifuroxazide (NX) analogues, such as 5-nitro-2-furfuryliden and 5-nitro-2-theniliden derivatives, were performed. A molecular modeling approach was also carried out to relate the lipophilicity potential (LP) property and biological activity data.
Akilimali Shindano et al.
Acta gastro-enterologica Belgica, 70(1), 32-33 (2007-07-11)
We report the case of a middle-aged woman who developed a typical picture of acute pancreatitis together with systemic features of immunoallergy after the intake of two capsules (200 mg) of nifuroxazide. Even if acute pancreatitis is a rare adverse
Philippe Quillardet et al.
Mutagenesis, 21(5), 305-311 (2006-08-10)
Nitrofurans are widely used in human medicine, as nitrofurantoin and nifuroxazide, still prescribed for long-term antimicrobial prophylaxis of urinary tract and gastrointestinal infection in humans respectively. Recent experiments in mammals, as well as reports mentioning toxic effects in humans associated
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