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46392

Sigma-Aldrich

Flunarizine dihydrochloride

≥98.0% (TLC)

Synonym(s):

1-[Bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C26H26F2N2 · 2HCl
CAS Number:
30484-77-6
Molecular Weight:
477.42
Beilstein:
4284243
EC Number:
250-216-6
MDL number:
MFCD00058198
UNSPSC Code:
12352203

Assay

≥98.0% (TLC)

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

solubility

chloroform/methanol (9:1): 50 mg/mL, clear, colorless

application(s)

forensics and toxicology
veterinary

SMILES string

Cl[H].Cl[H].Fc1ccc(cc1)C(N2CCN(CC2)C\C=C\c3ccccc3)c4ccc(F)cc4

InChI

1S/C26H26F2N2.2ClH/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21;;/h1-15,26H,16-20H2;2*1H/b7-4+;;

InChI key

RXKMOPXNWTYEHI-RDRKJGRWSA-N

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Biochem/physiol Actions

Blocks T-type Ca2+/Na+ channels; inhibits K+-induced catecholamine release from chromaffin cells

Other Notes

Calcium antagonist. Selectively blocks T-type calcium channels

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K Takahashi et al.
The Journal of pharmacology and experimental therapeutics, 256(1), 169-175 (1991-01-01)
In CA1 pyramidal cells freshly isolated from the rat hippocampus, the low-threshold (T-type) Ca++ current was induced by step depolarization to potentials more positive than about -60 mV from a holding potential of -100 mV, and reached a peak in

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