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Furazolidone

VETRANAL®, analytical standard

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Synonym(s):
3-(5-Nitrofurfurylideneamino)-2-oxazolidinone
Empirical Formula (Hill Notation):
C8H7N3O5
CAS Number:
67-45-8
Molecular Weight:
225.16
Beilstein:
8317414
EC Number:
200-653-3
MDL number:
MFCD00010550
UNSPSC Code:
41116107
PubChem Substance ID:
329757127
NACRES:
NA.24

grade

analytical standard

Quality Level

200

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

antibiotic activity spectrum

Gram-positive bacteria
parasites

application(s)

cleaning products
clinical
cosmetics
food and beverages
forensics and toxicology
personal care
pharmaceutical (small molecule)

format

neat

Mode of action

enzyme | inhibits

SMILES string

[O-][N+](=O)c1ccc(\C=N\N2CCOC2=O)o1

InChI

1S/C8H7N3O5/c12-8-10(3-4-15-8)9-5-6-1-2-7(16-6)11(13)14/h1-2,5H,3-4H2/b9-5+

InChI key

PLHJDBGFXBMTGZ-WEVVVXLNSA-N

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General description

Furazolidone is an effective antiprotozoal and antibacterial agent.

Application

Furazolidone may be used as a reference standard:
  • For the determination of the analyte in pharmaceutical formulations by second-derivative spectrophotometry.
  • For the determination of the analyte in animal feeds using liquid chromatography with ultraviolet and thermospray mass spectrometric detection.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

related product

Product No.
Description
Pricing

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H361fd

Hazard Classifications

Repr. 2

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

新产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Formulation and advantages of furazolidone in liposomal drug delivery systems.
Alam MI, et al.
European Journal of Pharmaceutical Sciences, 84, 139- 145 (2016)
Determination of furazolidone in animal feeds using liquid chromatography with UV and thermospray mass spectrometric detection.
McCracken RJ and Kennedy DG
Journal of Chromatography A, 771(1-2), 349- 354 (1997)
C V Prasad et al.
Journal of pharmaceutical and biomedical analysis, 21(5), 961-968 (2000-03-07)
A second-derivative spectrophotometric procedure has been developed for the simultaneous determination of tinidazole (TD), furazolidone (FD) and diloxanide furoate (DF) in a commercial preparation. The method consists of the utilization of second-derivative absorption spectra of tablet extract in distilled water
André Gustavo Tempone et al.
International journal of antimicrobial agents, 36(2), 159-163 (2010-06-18)
Drug delivery systems are promising pharmaceutical formulations used to improve the therapeutic index of drugs. In this study, we developed a liposomal formulation of furazolidone that targets Leishmania (Leishmania) chagasi amastigotes in a hamster model. Using laser scanning confocal microscopy
B H Ali
Veterinary research communications, 6(1), 1-11 (1983-01-01)
The pharmacological and toxicological properties of furazolidone have been briefly reviewed. Among the most important pharmacological actions of furazolidone is the inhibition of mono- and diamine oxidase activities, which seem to depend, at least in some species, on the presence
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