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43665

Sigma-Aldrich

Direct Red 80

for microscopy

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Synonym(s):
Sirius Red
Empirical Formula (Hill Notation):
C45H26N10Na6O21S6
CAS Number:
2610-10-8
Molecular Weight:
1373.07
Colour Index Number:
35780
Beilstein:
8185575
EC Number:
220-027-3
MDL number:
MFCD00054389
UNSPSC Code:
12171500
PubChem Substance ID:
24866989

grade

for microscopy

SMILES string

[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].Oc1c(\N=N\c2ccc(cc2S([O-])(=O)=O)\N=N\c3ccc(cc3)S([O-])(=O)=O)c(cc4cc(NC(=O)Nc5ccc6c(O)c(\N=N\c7ccc(cc7S([O-])(=O)=O)\N=N\c8ccc(cc8)S([O-])(=O)=O)c(cc6c5)S([O-])(=O)=O)ccc14)S([O-])(=O)=O

InChI

1S/C45H32N10O21S6.6Na/c56-43-33-13-5-27(17-23(33)19-39(81(71,72)73)41(43)54-52-35-15-7-29(21-37(35)79(65,66)67)50-48-25-1-9-31(10-2-25)77(59,60)61)46-45(58)47-28-6-14-34-24(18-28)20-40(82(74,75)76)42(44(34)57)55-53-36-16-8-30(22-38(36)80(68,69)70)51-49-26-3-11-32(12-4-26)78(62,63)64;;;;;;/h1-22,56-57H,(H2,46,47,58)(H,59,60,61)(H,62,63,64)(H,65,66,67)(H,68,69,70)(H,71,72,73)(H,74,75,76);;;;;;/q;6*+1/p-6/b50-48+,51-49+,54-52+,55-53+;;;;;;

InChI key

YIQKLZYTHXTDDT-IJPLDVMMSA-H

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Other Notes

This product has been replaced by 365548-Sigma-Aldrich | Direct Red 80 Dye content 25 %
Stain used to demonstrate collagenous septa (picrosirius red technique)

replaced by

Product No.
Description
Pricing

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

新产品

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G E Piérard
Matrix (Stuttgart, Germany), 9(1), 68-71 (1989-01-01)
There are several reports in the literature where the sirius red polarization method is used to identify the molecular type of collagen in tissue sections. We present evidence that such way of interpretation is erroneous. The sirius red polarization method
P C Dolber et al.
Stain technology, 62(1), 23-26 (1987-01-01)
When the picrosirius red technique was applied to cardiac muscle sections, intense yellow myocyte staining sometimes obscured thin collagenous septa. The picrosirius red technique was modified to include treatment of the sections in 0.2% (w/v) aqueous phosphomolybdic acid prior to
Corrine R Kliment et al.
International journal of clinical and experimental pathology, 4(4), 349-355 (2011-05-18)
The purpose of this study was to develop an improved method for collagen and protein assessment of fibrotic lungs while decreasing animal use. 8-10 week old, male C57BL/6 mice were given a single intratracheal instillation of crocidolite asbestos or control
SIRIUS RED F3BA AS A STAIN FOR CONNECTIVE TISSUE.
F SWEAT et al.
Archives of pathology, 78, 69-72 (1964-07-01)
Christopher A Miller et al.
Circulation. Cardiovascular imaging, 6(3), 373-383 (2013-04-05)
Extracellular matrix expansion is a key element of ventricular remodeling and a potential therapeutic target. Cardiovascular magnetic resonance (CMR) T1-mapping techniques are increasingly used to evaluate myocardial extracellular volume (ECV); however, the most widely applied methods are without histological validation.
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