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β-Alanine

analytical standard

Synonym(s):

β-Ala, 3-Aminopropionic acid

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About This Item

Linear Formula:
NH2CH2CH2COOH
CAS Number:
Molecular Weight:
89.09
Beilstein:
906793
EC Number:
MDL number:
UNSPSC Code:
85151701
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

Assay

≥98.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

analyte chemical class(es)

amino acids, peptides, proteins

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

impurities

≤0.3% water

color

white to off-white

mp

202 °C (dec.) (lit.)

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care

format

neat

SMILES string

NCCC(O)=O

InChI

1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6)

InChI key

UCMIRNVEIXFBKS-UHFFFAOYSA-N

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General description

β-Alanine is a rate-limiting precursor of carnosine, a cytoplasmic dipeptide which is present in human skeletal muscles in high concentrations.

Application

β-Alanine may be used as a reference standard for the determination of β-alanine in:
  • Potato tubers by gas chromatography-mass spectrometry (GC-MS).
  • Human plasma, urine, and cerebrospinal fluid samples by liquid chromatography-tandem mass spectrometry (LC-MS/MS).
  • Striatal microdialysis samples by high performance liquid chromatography-fluorescence detection (HPLC-FLD) with ortho-phthalaldehyde-mercaptoethanol derivatization.
  • Fermented soybean paste, Cheonggukjang, by GC-MS operating in selected-ion monitoring (SIM) mode and principal component analysis (PCA).

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

β-Alanine, a β−amino acid, is a component of pantothenic acid and the rate-limiting amino acid in the biosynthesis of the histidinyl antioxidant dipeptides carnosine and anserine. Endogenous β-amino acid that is a nonselective agonist at glycine receptors and a ligand for the G protein-coupled orphan receptor, TGR7 (MrgD). β-Alanine flux plays a cytoprotective role by supporting the osmotic stability of marine organisms, preimplantation mouse embryos and mammalian cells exposed to hypoxic stress.

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Certificates of Analysis (COA)

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Rapid and sensitive step gradient assays of glutamate, glycine, taurine and $\gamma$-aminobutyric acid by high-performance liquid chromatography-fluorescence detection with o-phthalaldehyde-mercaptoethanol derivatization with an emphasis on microdialysis samples
Piepponen TP and Skujins A
Journal of Chromatography. B, Biomedical Sciences and Applications, 757(2), 277-283 (2001)
A rapid, sensitive method for quantitative analysis of underivatized amino acids by liquid chromatography-tandem mass spectrometry (LC-MS/MS)
Le A, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 944(1), 166-174 (2014)
Simultaneous analysis of metabolites in potato tuber by gas chromatography-mass spectrometry
Roessner U, et al.
The Plant Journal, 23(1), 131-142 (2000)
Metabolite profiling of Cheonggukjang, a fermented soybean paste, during fermentation by gas chromatography-mass spectrometry and principal component analysis
Park MK, et al.
Food Chemistry, 122(4), 1313-1319 (2010)
?-Alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprinters
Derave W, et al.
Journal of Applied Physiology, 103(5), 1736-1743 (2007)

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