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Merck
CN

38907

Isorhamnetin

analytical standard

Synonym(s):

3′-Methoxy-3,4′,5,7-tetrahydroxyflavone, 3′-Methylquercetin, 3,4′,5,7-Tetrahydroxy 3′-methoxyflavone, Isorhamnetol, Quercetin 3′-methyl ether

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About This Item

Empirical Formula (Hill Notation):
C16H12O7
CAS Number:
480-19-3
Molecular Weight:
316.26
UNSPSC Code:
85151701
NACRES:
NA.24
PubChem Substance ID:
329755802
EC Number:
207-545-5
Beilstein/REAXYS Number:
44723
MDL number:
MFCD00017310

Key Documents

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InChI

1S/C16H12O7/c1-22-11-4-7(2-3-9(11)18)16-15(21)14(20)13-10(19)5-8(17)6-12(13)23-16/h2-6,17-19,21H,1H3

SMILES string

COc1cc(ccc1O)C2=C(O)C(=O)c3c(O)cc(O)cc3O2

InChI key

IZQSVPBOUDKVDZ-UHFFFAOYSA-N

grade

analytical standard

assay

≥99% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

food and beverages

format

neat

storage temp.

2-8°C

Quality Level

100

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General description

Isorhamnetin belongs to the flavonoids class of compounds.

Application

Isorhamnetin may be used as an analytical reference standard for the determination of isorhamnetin in:
  • Rat plasma samples by ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) equipped with electrospray ionization (ESI) and multiple reaction monitoring (MRM) mode of detection.
  • Lotus (Nelumbo nucifera) leaves by macroporous resin chromatography combined with HPLC-ESI-MS/MS.
  • Powdered extracts and finished products samples of Ginkgo biloba by HPLC-MS.
  • Human plasma and urine by high-throughput micro solid-phase extraction (μ-SPE), followed by analysis using UHPLC in interface with quadrupole time-of-flight mass spectrometry (Q TOFMS).

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Isorhamnetin inhibits adipogenesis by interfering with differentiation of adipose stem cells, by a mechanism involving stabilization of β-catenin and up-regulating the Wnt signaling pathway.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

This compound is commonly found in plants of the genus: ginkgo glycyrrhiza primula

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN7849
BCCL9260
BCCL0551
BCCJ5826
BCCG9742

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Development and validation of a high-throughput micro solid-phase extraction method coupled with ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry for rapid identification and quantification of phenolic metabolites in human plasma and urine.
Feliciano RP, et al.
Journal of Chromatography A, 1464(4), 21-31 (2016)
Chemical fingerprint and quantitative analysis of flavonoids for quality control of Sea buckthorn leaves by HPLC and UHPLC-ESI-QTOF-MS.
Dong R, et al.
Journal of functional foods, 37, 513-522 (2017)
Simultaneous Determination of Kaempferide, Kaempferol and Isorhamnetin in Rat Plasma by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry and its Application to a Pharmacokinetic Study.
Jiang Z, et al.
Journal of the Brazilian Chemical Society, 29(3), 535-542 (2018)
An effective identification and quantification method for Ginkgo biloba flavonol glycosides with targeted evaluation of adulterated products.
Ma YC, et al.
Phytomedicine, 23(4), 377-387 (2016)
Analysis of flavonoids in lotus (Nelumbo nucifera) leaves and their antioxidant activity using macroporous resin chromatography coupled with LC-MS/MS and antioxidant biochemical assays.
Zhu MZ, et al.
Molecules (Basel), 20(6), 10553-10565 (2015)
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