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Merck
CN

34888-M

Acetonitrile

≥99.9%, for HPLC, for UV, suitable for HPLC

Synonym(s):

ACN, Cyanomethane, Ethyl nitrile, Methyl cyanide

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About This Item

Linear Formula:
CH3CN
CAS Number:
75-05-8
Molecular Weight:
41.05
UNSPSC Code:
41116004
NACRES:
NA.03
EC Number:
200-835-2
Beilstein/REAXYS Number:
741857
MDL number:
MFCD00001878
Assay:
≥99.9%
Technique(s):
HPLC: suitable
Bp:
81-82 °C (lit.)
Vapor pressure:
72.8 mmHg ( 20 °C)

Key Documents

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Product Name

Acetonitrile, ≥99.9%

InChI key

WEVYAHXRMPXWCK-UHFFFAOYSA-N

InChI

1S/C2H3N/c1-2-3/h1H3

SMILES string

CC#N

vapor density

1.41 (vs air)

vapor pressure

72.8 mmHg ( 20 °C)

assay

≥99.9%

form

liquid

autoignition temp.

973 °F

expl. lim.

16 %

technique(s)

HPLC: suitable

impurities

≤0.0002% free alkali (NH3)
≤0.002% free acid (as CH3COOH)
≤0.02% water
≤0.5 ppb fluorescence (quinine) at 365 nm
≤1 ppb fluorescence (quinine) at 254 nm

evapn. residue

≤0.0005%

transmittance

195 nm, ≥65%
200 nm, ≥88%
210 nm, ≥93%
235 nm, ≥99%

refractive index

n20/D 1.344 (lit.)

bp

81-82 °C (lit.)

mp

−45 °C (lit.)

density

0.786 g/mL at 25 °C (lit.)

format

neat

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Application

Acetonitrile can be used as a component in:
  • Mobile phase mixture for the HPLC analysis, to determine the purity of ester content (%FAME).
  • Mobile phase for the ultra-performance liquid chromatography (UPLC) analysis of perfluoroalkyl carboxylic and sulfonic compounds.
  • Mobile phase for high-performance liquid chromatography (HPLC), enabling the effective separation of TMP (trimethoprim) and SMX (sulfamethoxazole).
  • For sample preparation, including extraction, dilution, and dissolutionof compounds prior to analysis.

General description

Acetonitrile is a widely used organic solvent in reversed-phase liquid chromatography due to its high miscibility with water, suitable UV absorbance properties, and low viscosity characteristics.

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

35.6 °F - closed cup

flash_point_c

2.0 °C - closed cup

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SDBB4695
SDBB4220
SDBB3785
SDBB2793
SDBB1663

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Effects of the antibiotics trimethoprim (TMP) and sulfamethoxazole (SMX) on granulation, microbiology, and performance of aerobic granular sludge systems
Barros ARM, et al.
Chemosphere, 262, 127840-127840 (2021)
Kinetic model for sonolytic degradation of non-volatile surfactants: Perfluoroalkyl substances
Shende T, et al.
Ultrasonics Sonochemistry, 51, 359-368 (2019)
A rapid, acetonitrile-free, HPLC method for determination of melamine in infant formula
Venkatasami G, et al.
Analytica Chimica Acta, 665(2), 227-230 (2010)

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