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34202

Supelco

Finasteride

VETRANAL®, analytical standard

Synonym(s):

N-(2-methyl-2-propyl)-3-oxo-4-aza-5α-androst-1-ene-17β-carboxamide, N-tert-Butyl-3-oxo-4-aza-5α-androst-1-en-17β-carboxamide, MK-906

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About This Item

Empirical Formula (Hill Notation):
C23H36N2O2
CAS Number:
98319-26-7
Molecular Weight:
372.54
MDL number:
MFCD00869737
UNSPSC Code:
41116107
PubChem Substance ID:
329754889

grade

analytical standard

Quality Level

100

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

[H][C@@]12CC[C@@]3([H])[C@]4([H])CC[C@H](C(=O)NC(C)(C)C)[C@@]4(C)CC[C@]3([H])[C@@]1(C)C=CC(=O)N2

InChI

1S/C23H36N2O2/c1-21(2,3)25-20(27)17-8-7-15-14-6-9-18-23(5,13-11-19(26)24-18)16(14)10-12-22(15,17)4/h11,13-18H,6-10,12H2,1-5H3,(H,24,26)(H,25,27)/t14-,15-,16-,17+,18+,22-,23+/m0/s1

InChI key

DBEPLOCGEIEOCV-WSBQPABSSA-N

Gene Information

human ... SRD5A2(6716)

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Application

Finasteride may be used as an analytical reference standard for the determination of the analyte in biological fluids and pharmaceutical formulations by high performance liquid chromatography (HPLC) method.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Selective 5α-reductase inhibitor; antiandrogen.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

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Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Statements

H302,H360FD

Hazard Classifications

Acute Tox. 4 Oral - Repr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

监管及禁止进口产品

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Certificates of Analysis (COA)

Lot/Batch Number
BCCD8558

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High-performance liquid chromatographic determination of finasteride in human plasma using direct injection with column switching.
Takano T and Hata S
Journal of Chromatography. B, Biomedical Sciences and Applications, 676(1), 141-146 (1996)
Determination of finasteride in tablets by high performance liquid chromatography.
Basavaiah K and Somashekar BC
Journal of Chemistry, 4(1), 109-116 (2007)
Asad Umar et al.
Nature reviews. Cancer, 12(12), 835-848 (2012-11-16)
Prevention of cancer remains the most promising strategy for reducing both its incidence and the mortality due to this disease. For more than four decades, findings from epidemiology, basic research and clinical trials have informed the development of lifestyle and
Mary K Samplaski et al.
Fertility and sterility, 100(6), 1542-1546 (2013-09-10)
To determine the degree of improvement in semen parameters after finasteride discontinuation. A prospective database of men presenting for a fertility evaluation was analyzed for semen and hormone parameters before and after discontinuation of finasteride. A male infertility specialty clinic.
Teemu J Murtola et al.
The Prostate, 73(9), 923-931 (2013-01-22)
Two clinical trials have shown that users of 5α-reductase inhibitors finasteride and dutasteride (5-ARIs) have reduced overall prostate cancer risk, while the proportion of high-grade tumors is increased. We studied tumor characteristics, risk of biochemical recurrence and mortality after radical
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