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34124

Supelco

Deoxynivalenol solution

100 μg/mL in acetonitrile, analytical standard

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Synonym(s):
3α,7α,15-Trihydroxy-12,13-epoxytrichothec-9-en-8-one, DON, Vomitoxin
Empirical Formula (Hill Notation):
C15H20O6
CAS Number:
51481-10-8
Molecular Weight:
296.32
EC Number:
200-835-2
MDL number:
MFCD09039270
UNSPSC Code:
85151701
PubChem Substance ID:
329754831
NACRES:
NA.24

grade

analytical standard

Quality Level

100

shelf life

limited shelf life, expiry date on the label

concentration

100 μg/mL in acetonitrile

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

cleaning products
cosmetics
food and beverages
personal care

format

single component solution

storage temp.

−20°C

SMILES string

CC1=C[C@H]2O[C@@H]3[C@H](O)C[C@@](C)([C@]34CO4)[C@@]2(CO)[C@H](O)C1=O

InChI

1S/C15H20O6/c1-7-3-9-14(5-16,11(19)10(7)18)13(2)4-8(17)12(21-9)15(13)6-20-15/h3,8-9,11-12,16-17,19H,4-6H2,1-2H3/t8-,9-,11-,12-,13-,14-,15+/m1/s1

InChI key

LINOMUASTDIRTM-QGRHZQQGSA-N

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General description

Deoxynivalenol belongs to the group of tetracyclic sesquiterpenoid mycotoxins called trichothecenes, produced by Fusarium fungi, naturally occurring in small grains and infected corn.

Check out our entire range of trichothecene type mycotoxin reference materials
Deoxynivalenol is frequently found in cereals and agricultural products including, corn, barley, oats, rye, maize, wheat, malt, bread, beer, etc. It is a mycotoxin and primarily affects the livestock industry by reducing the food intake in farm animals. The effect of DON contamination in cereals and other food samples serves as one of the factors of Kashin-Beck disease, a chronic and endemic osteoarticular disorder.

Application

Deoxynivalenol solution has been used as an analytical reference standard for the quantification of the analyte in cornmeal and wheat meal matrices using high-performance liquid chromatography with UV detection (HPLC-UV). It is used as an analytical standard in investigating its toxicity mechanism on human chondrocytes by microarray and bioinformatics analysis.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

FlameExclamation mark
GHS02,GHS07

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

WGK

WGK 2

Flash Point(F)

closed cup

Flash Point(C)

closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

高风险级别生物产品--毒素类产品
危险化学品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Determination of 12 type A and B trichothecenes in cereals by liquid chromatography? electrospray ionization tandem mass spectrometry
Klotzel M, et al.
Journal of Agricultural and Food Chemistry, 53, 8904-8910 (2005)
Production of monoclonal antibodies for the specific detection of deoxynivalenol and 15-acetyldeoxynivalenol by ELISA
Sinha.CR, et al.
Journal of Agricultural and Food Chemistry, 43, 1740-1744 (1995)
Lei Yang et al.
Toxicology letters, 321, 61-68 (2019-12-22)
T-2 toxin and deoxynivalenol (DON) are two representative mycotoxins that are commonly found in cereals and agricultural products. As T-2 toxin and DON are considered the cause of Kashin-Beck disease, a special osteoarticular disease, chondrocytes would be a vital target
Giuseppina Avantaggiato et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 42(5), 817-824 (2004-03-30)
In vitro screening of 14 adsorbent materials, including some commercial products used to detoxify Fusarium-mycotoxins, were tested in the pH range of 3-8 for deoxynivalenol (DON)- and nivalenol (NIV)-binding ability. Only activated carbon showed to be effective with binding capacities
Michihiro Ito et al.
Applied and environmental microbiology, 79(5), 1619-1628 (2013-01-01)
Deoxynivalenol (DON) is a natural toxin of fungi that cause Fusarium head blight disease of wheat and other small-grain cereals. DON accumulates in infected grains and promotes the spread of the infection on wheat, posing serious problems to grain production.
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