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Merck
CN

33993

Doramectin

VETRANAL®, analytical standard

Synonym(s):

25-Cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)avermectin

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About This Item

Empirical Formula (Hill Notation):
C50H74O14
CAS Number:
117704-25-3
Molecular Weight:
899.11
NACRES:
NA.24
PubChem Substance ID:
329754732
UNSPSC Code:
41116107
MDL number:
MFCD00894747

Key Documents

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InChI

1S/C50H74O14/c1-27-13-12-16-34-26-57-47-42(51)30(4)21-37(50(34,47)54)48(53)60-36-22-35(63-49(25-36)20-19-29(3)45(64-49)33-14-10-9-11-15-33)18-17-28(2)44(27)61-41-24-39(56-8)46(32(6)59-41)62-40-23-38(55-7)43(52)31(5)58-40/h12-13,16-17,19-21,27,29,31-33,35-47,51-52,54H,9-11,14-15,18,22-26H2,1-8H3/b13-12+,28-17+,34-16+/t27-,29-,31-,32-,35?,36-,37-,38-,39-,40+,41+,42+,43-,44-,45-,46-,47+,49+,50+/m0/s1

SMILES string

[H][C@@]12OC/C3=C\C=C\[C@H](C)[C@H](O[C@@H]4C[C@H](OC)[C@@H](O[C@@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)\C(C)=C\CC6C[C@@H](C[C@]7(O6)O[C@@H]([C@@H](C)C=C7)C8CCCCC8)OC(=O)[C@H](C=C(C)[C@H]1O)[C@@]23O

InChI key

QLFZZSKTJWDQOS-TTXKVKCHSA-N

grade

analytical standard

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

agriculture
environmental

format

neat

storage temp.

−20°C

Quality Level

100

Related Categories

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

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Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Lact. - Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
BCCN9945
BCCN3630
BCCM6191
BCCH8061
BCCJ1205

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Ginger L Takle et al.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 41(3), 496-502 (2010-10-16)
One female and two male 4-mo-old, sibling rock hyraxes (Procavia capensis) presented with severe generalized dermatitis characterized by nonpruritic, nonalopecic, mildly encrusted, focally, ulcerated pustular nodules. The dorsum, limbs, and dorsal cranium were most severely affected. Skin scrapings, histopathology, and
Xiang-Jing Wang et al.
Chemistry & biodiversity, 8(11), 2117-2125 (2011-11-16)
Four new doramectin congeners, 1-4, were isolated from Streptomyces avermitilis NEAU1069. The structures of 1-4 were elucidated on the basis of spectroscopic analysis, including 1D- and 2D-NMR as well as HR-ESI-MS, ESI-MS, UV, and IR, and comparison with literature data.
Jan Antonić et al.
Veterinary parasitology, 179(1-3), 159-166 (2011-04-07)
The aim of to the present study was to evaluate the effects of verapamil (VER) on plasma pharmacokinetics of ivermectin (IVM) and doramectin (DOR) in lactating Istrian Pramenka dairy sheep and to investigate the role of P-glycoprotein (P-gp) in transport
C Gokbulut et al.
Laboratory animals, 44(2), 138-142 (2009-12-05)
This study evaluated the comparative plasma dispositions of ivermectin (IVM), doramectin (DRM) and moxidectin (MXD) following subcutaneous administration in rabbits. Fifteen New Zealand white rabbits were allocated into three groups of five animals each. The animals in each group received
Efficacy of weekly oral doramectin treatment in canine demodicosis.
N Murayama et al.
The Veterinary record, 167(2), 63-64 (2010-07-14)
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