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Robenidine hydrochloride

VETRANAL®, analytical standard

Synonym(s):

1,3-Bis[(4-chlorobenzylidene)amino]guanidine monohydrochloride

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About This Item

Empirical Formula (Hill Notation):
C15H13Cl2N5 · HCl
CAS Number:
25875-50-7
Molecular Weight:
370.66
EC Number:
247-307-8
MDL number:
MFCD01724404
UNSPSC Code:
41116107
PubChem Substance ID:
329754719
NACRES:
NA.24

grade

analytical standard

Quality Level

100

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

Cl[H].Clc1ccc(cc1)\C=N\NC(=N)N\N=C\c2ccc(Cl)cc2

InChI

1S/C15H13Cl2N5.ClH/c16-13-5-1-11(2-6-13)9-19-21-15(18)22-20-10-12-3-7-14(17)8-4-12;/h1-10H,(H3,18,21,22);1H/b19-9+,20-10+;

InChI key

LTWIBTYLSRDGHP-HCURTGQUSA-N

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General description

Robenidine hydrochloride is a coccidiostat and antibiotic, used in controlling coccidiosis.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Robenidine hydrochloride has been used as a reference standard in the determination of robenidine hydrochloride in eggs using online solid-phase extraction with liquid chromatography coupled with tandem mass spectrometry (SPE-LC-MS/MS).

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

related product

Product No.
Description
Pricing

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCJ1061
BCBW6546
BCBS8398V
SZBD099XV
SZBA074XV

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Robin Das Gupta et al.
Antimicrobial agents and chemotherapy, 49(7), 2857-2864 (2005-06-28)
The intraerythrocytic development of Plasmodium falciparum correlates with increasing levels of the polyamines putrescine, spermidine, and spermine in the infected red blood cells; and compartmental analyses revealed that the majority is associated with the parasite. Since depletion of cellular polyamines
R Brun et al.
Tropical medicine & international health : TM & IH, 6(5), 362-368 (2001-05-12)
CGP 40 215 is an inhibitor of S-adenosylmethionine decarboxylase, a key enzyme in trypanosomal polyamine biosynthesis. It is highly active against Trypanosoma brucei rhodesiense and T. b. gambiense in vitro and in the corresponding rodent models, and therefore was a
Martin Hansen et al.
Environmental pollution (Barking, Essex : 1987), 157(2), 474-480 (2008-11-04)
The antibacterial potency of eight anticoccidial drugs was tested in a soil bacteria bioassay (pour plate method), EC(50)-values between 2.4 and 19.6 microM were obtained; however, one compound, nicarbazin exhibited an EC(50)-value above the maximum tested concentration (21 microM, 9.1
Binh Nguyen et al.
Biophysical journal, 90(4), 1319-1328 (2005-11-22)
The energetics for binding of a diphenyl diamidine antitrypanosomal agent CGP 40215A to DNA have been studied by spectroscopy, isothermal titration calorimetry, and surface plasmon resonance biosensor methods. Both amidines are positively charged under experimental conditions, but the linking group
J E Peeters et al.
Veterinary parasitology, 29(4), 327-331 (1988-10-01)
Caecal samples were collected from 751 domestic rabbits of various origin and from 1229 diarrhoeic rabbits issued from 61 commercial rabbitries. They were screened for coccidiosis. In 1982, the year of introduction of the anticoccidial robenidine in commercial rabbit feeds
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