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Merck
CN

33930

Fleroxacin

VETRANAL®, analytical standard

Synonym(s):

6,8-Difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methylpiperazino)-4-oxo-3-quinolinecarboxylic acid, 6,8-Difluoro-1-(2-fluoroethyl)1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid, AM-833, Megalocin, Megalone

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About This Item

Empirical Formula (Hill Notation):
C17H18F3N3O3
CAS Number:
79660-72-3
Molecular Weight:
369.34
NACRES:
NA.24
PubChem Substance ID:
329754700
UNSPSC Code:
41116107
MDL number:
MFCD00864880

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InChI

1S/C17H18F3N3O3/c1-21-4-6-22(7-5-21)15-12(19)8-10-14(13(15)20)23(3-2-18)9-11(16(10)24)17(25)26/h8-9H,2-7H2,1H3,(H,25,26)

SMILES string

CN1CCN(CC1)c2c(F)cc3C(=O)C(=CN(CCF)c3c2F)C(O)=O

InChI key

XBJBPGROQZJDOJ-UHFFFAOYSA-N

grade

analytical standard

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

100

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General description

Fleroxacin is an antimicrobial drug, belonging to the class of fluoroquinolones (FQs), which shows broad-spectrum activity against a wide range of Gram-negative and Gram-positive organisms.

Application

Fleroxacin may be used as an analytical reference standard for the determination of the analyte in biological fluids using various chromatography techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCBW5296

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Determination of the new fluoroquinolone fleroxacin and its N-demethyl and N-oxide metabolites in plasma and urine by high-performance liquid chromatography with fluorescence detection.
Heizmann P, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 527, 91-101 (1990)
High-performance liquid chromatography for the determination of three new fluoroquinolones, fleroxacin, temafloxacin and A-64730, in biological fluids.
Koechlin C, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 491, 379-387 (1989)
Rui-qin Feng et al.
Guang pu xue yu guang pu fen xi = Guang pu, 25(9), 1468-1470 (2005-12-29)
Based on the complex formed by Zn2+ which can strengthen the relative fluorescence intensity of fleroxacin evidently, a novel photochemical fluorescence method was developed. The effects of the acidity, the concentration ratio of Zn2+ to fleroxacin, and the time for
Toru Nishikawa et al.
Urology, 74(6), 1370-1376 (2009-05-12)
To study the antitumor effects of fleroxacin against bladder tumor cell lines and the synergistic effect with 5-fluorouracil (5-FU) both in vitro and in vivo. In vitro, the MBT-2 and T-24 urothelial carcinoma cell lines were exposed to fleroxacin in
Yongxia Fan et al.
Electrophoresis, 28(22), 4101-4107 (2007-10-18)
A rapid CE coupled with potential gradient detection (PGD) for the separation and detection of four quinolones, namely, enoxacin, ofloxacin (OFL), fleroxacin, and pazufloxacin, was described. Separation was performed in a fused-silica capillary (75 microm x 8.5 cm) using a
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